Roche D - Search Results

1

Structure-Activity Relationship in the Leucettine Family of Kinase Inhibitors.

Tahtouh T, Durieu E, Villiers B, Bruyère C, Nguyen TL, Fant X, Ahn KH, Khurana L, Deau E, Lindberg MF, Sévère E, Miege F, Roche D, Limanton E, L'Helgoual'ch JM, Burgy G, Guiheneuf S, Herault Y, Kendall DA, Carreaux F, Bazureau JP, Meijer L. Tahtouh T, et al. Among authors: roche d. J Med Chem. 2022 Jan 27;65(2):1396-1417. doi: 10.1021/acs.jmedchem.1c01141. Epub 2021 Dec 20. J Med Chem. 2022. PMID: 34928152

2

Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.

Fournier JF, Clary L, Chambon S, Dumais L, Harris CS, Millois C, Pierre R, Talano S, Thoreau É, Aubert J, Aurelly M, Bouix-Peter C, Brethon A, Chantalat L, Christin O, Comino C, El-Bazbouz G, Ghilini AL, Isabet T, Lardy C, Luzy AP, Mathieu C, Mebrouk K, Orfila D, Pascau J, Reverse K, Roche D, Rodeschini V, Hennequin LF. Fournier JF, et al. Among authors: roche d. J Med Chem. 2018 May 10;61(9):4030-4051. doi: 10.1021/acs.jmedchem.8b00067. Epub 2018 Apr 24. J Med Chem. 2018. PMID: 29648825

3

Discovery and structure-guided drug design of inhibitors of 11beta-hydroxysteroid-dehydrogenase type I based on a spiro-carboxamide scaffold.

Lepifre F, Christmann-Franck S, Roche D, Leriche C, Carniato D, Charon C, Bozec S, Doare L, Schmidlin F, Lecomte M, Valeur E. Lepifre F, et al. Among authors: roche d. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3682-5. doi: 10.1016/j.bmcl.2009.02.123. Epub 2009 Mar 5. Bioorg Med Chem Lett. 2009. PMID: 19450980

4

Synthesis and biological properties of macrolactam analogs of the natural product macrolide (-)-A26771B.

Canova S, Lépine R, Thys A, Baron A, Roche D. Canova S, et al. Among authors: roche d. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4768-72. doi: 10.1016/j.bmcl.2011.06.073. Epub 2011 Jun 23. Bioorg Med Chem Lett. 2011. PMID: 21767951

5

Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies.

Grädler U, Schwarz D, Blaesse M, Leuthner B, Johnson TL, Bernard F, Jiang X, Marx A, Gilardone M, Lemoine H, Roche D, Jorand-Lebrun C. Grädler U, et al. Among authors: roche d. Bioorg Med Chem Lett. 2019 Dec 1;29(23):126717. doi: 10.1016/j.bmcl.2019.126717. Epub 2019 Oct 16. Bioorg Med Chem Lett. 2019. PMID: 31635932 Free PMC article.

6

Novel 2,7-Diazaspiro[4,4]nonane Derivatives to Inhibit Mouse and Human Osteoclast Activities and Prevent Bone Loss in Ovariectomized Mice without Affecting Bone Formation.

Mounier L, Morel A, Ferrandez Y, Morko J, Vääräniemi J, Gilardone M, Roche D, Cherfils J, Blangy A. Mounier L, et al. Among authors: roche d. J Med Chem. 2020 Nov 25;63(22):13680-13694. doi: 10.1021/acs.jmedchem.0c01201. Epub 2020 Nov 11. J Med Chem. 2020. PMID: 33175535

7

Design and synthesis of potent and selective inhibitors of integrin VLA-4.

Wattanasin S, Weidmann B, Roche D, Myers S, Xing A, Guo Q, Sabio M, von Matt P, Hugo R, Maida S, Lake P, Weetall M. Wattanasin S, et al. Among authors: roche d. Bioorg Med Chem Lett. 2001 Nov 19;11(22):2955-8. doi: 10.1016/s0960-894x(01)00586-8. Bioorg Med Chem Lett. 2001. PMID: 11677134

8

Discovery and structure-activity relationships of pentanedioic acid diamides as potent inhibitors of 11beta-hydroxysteroid dehydrogenase type I.

Roche D, Carniato D, Leriche C, Lepifre F, Christmann-Franck S, Graedler U, Charon C, Bozec S, Doare L, Schmidlin F, Lecomte M, Valeur E. Roche D, et al. Bioorg Med Chem Lett. 2009 May 15;19(10):2674-8. doi: 10.1016/j.bmcl.2009.03.140. Epub 2009 Apr 1. Bioorg Med Chem Lett. 2009. PMID: 19395260

9

Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11β-hydroxysteroid dehydrogenase type I.

Valeur E, Christmann-Franck S, Lepifre F, Carniato D, Cravo D, Charon C, Bozec S, Musil D, Hillertz P, Doare L, Schmidlin F, Lecomte M, Schultz M, Roche D. Valeur E, et al. Among authors: roche d. Bioorg Med Chem Lett. 2012 Sep 15;22(18):5909-14. doi: 10.1016/j.bmcl.2012.07.070. Epub 2012 Jul 31. Bioorg Med Chem Lett. 2012. PMID: 22901389

10

Design, synthesis and decoration of molecular scaffolds for exploitation in the production of alkaloid-like libraries.

Craven P, Aimon A, Dow M, Fleury-Bregeot N, Guilleux R, Morgentin R, Roche D, Kalliokoski T, Foster R, Marsden SP, Nelson A. Craven P, et al. Among authors: roche d. Bioorg Med Chem. 2015 Jun 1;23(11):2629-35. doi: 10.1016/j.bmc.2014.12.048. Epub 2014 Dec 29. Bioorg Med Chem. 2015. PMID: 25600406

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