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Multi-Tissue Acceleration of the Mitochondrial Phosphoenolpyruvate Cycle Improves Whole-Body Metabolic Health.
Abulizi A, Cardone RL, Stark R, Lewandowski SL, Zhao X, Hillion J, Ma L, Sehgal R, Alves TC, Thomas C, Kung C, Wang B, Siebel S, Andrews ZB, Mason GF, Rinehart J, Merrins MJ, Kibbey RG. Abulizi A, et al. Among authors: rinehart j. Cell Metab. 2020 Nov 3;32(5):751-766.e11. doi: 10.1016/j.cmet.2020.10.006. Cell Metab. 2020. PMID: 33147485 Free PMC article.
Distinct Hepatic PKA and CDK Signaling Pathways Control Activity-Independent Pyruvate Kinase Phosphorylation and Hepatic Glucose Production.
Gassaway BM, Cardone RL, Padyana AK, Petersen MC, Judd ET, Hayes S, Tong S, Barber KW, Apostolidi M, Abulizi A, Sheetz JB, Kshitiz, Aerni HR, Gross S, Kung C, Samuel VT, Shulman GI, Kibbey RG, Rinehart J. Gassaway BM, et al. Among authors: rinehart j. Cell Rep. 2019 Dec 10;29(11):3394-3404.e9. doi: 10.1016/j.celrep.2019.11.009. Cell Rep. 2019. PMID: 31825824 Free PMC article.
A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance.
Lyu K, Zhang Y, Zhang D, Kahn M, Ter Horst KW, Rodrigues MRS, Gaspar RC, Hirabara SM, Luukkonen PK, Lee S, Bhanot S, Rinehart J, Blume N, Rasch MG, Serlie MJ, Bogan JS, Cline GW, Samuel VT, Shulman GI. Lyu K, et al. Among authors: rinehart j. Cell Metab. 2020 Oct 6;32(4):654-664.e5. doi: 10.1016/j.cmet.2020.08.001. Epub 2020 Sep 2. Cell Metab. 2020. PMID: 32882164 Free PMC article.
Comprehensive Analysis of Metabolic Isozyme Targets in Cancer.
Marczyk M, Gunasekharan V, Casadevall D, Qing T, Foldi J, Sehgal R, Shan NL, Blenman KRM, O'Meara TA, Umlauf S, Surovtseva YV, Muthusamy V, Rinehart J, Perry RJ, Kibbey R, Hatzis C, Pusztai L. Marczyk M, et al. Among authors: rinehart j. Cancer Res. 2022 May 3;82(9):1698-1711. doi: 10.1158/0008-5472.CAN-21-3983. Cancer Res. 2022. PMID: 35247885 Free PMC article.
Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance.
Petersen MC, Madiraju AK, Gassaway BM, Marcel M, Nasiri AR, Butrico G, Marcucci MJ, Zhang D, Abulizi A, Zhang XM, Philbrick W, Hubbard SR, Jurczak MJ, Samuel VT, Rinehart J, Shulman GI. Petersen MC, et al. Among authors: rinehart j. J Clin Invest. 2016 Nov 1;126(11):4361-4371. doi: 10.1172/JCI86013. Epub 2016 Oct 17. J Clin Invest. 2016. PMID: 27760050 Free PMC article.
Sites of regulated phosphorylation that control K-Cl cotransporter activity.
Rinehart J, Maksimova YD, Tanis JE, Stone KL, Hodson CA, Zhang J, Risinger M, Pan W, Wu D, Colangelo CM, Forbush B, Joiner CH, Gulcicek EE, Gallagher PG, Lifton RP. Rinehart J, et al. Cell. 2009 Aug 7;138(3):525-36. doi: 10.1016/j.cell.2009.05.031. Cell. 2009. PMID: 19665974 Free PMC article.
PKCε contributes to lipid-induced insulin resistance through cross talk with p70S6K and through previously unknown regulators of insulin signaling.
Gassaway BM, Petersen MC, Surovtseva YV, Barber KW, Sheetz JB, Aerni HR, Merkel JS, Samuel VT, Shulman GI, Rinehart J. Gassaway BM, et al. Among authors: rinehart j. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8996-E9005. doi: 10.1073/pnas.1804379115. Epub 2018 Sep 4. Proc Natl Acad Sci U S A. 2018. PMID: 30181290 Free PMC article.
567 results