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Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120).
Sparks SM, Chen G, Collins JL, Danger D, Dock ST, Jayawickreme C, Jenkinson S, Laudeman C, Leesnitzer MA, Liang X, Maloney P, McCoy DC, Moncol D, Rash V, Rimele T, Vulimiri P, Way JM, Ross S. Sparks SM, et al. Among authors: rimele t. Bioorg Med Chem Lett. 2014 Jul 15;24(14):3100-3. doi: 10.1016/j.bmcl.2014.05.012. Epub 2014 May 16. Bioorg Med Chem Lett. 2014. PMID: 24881566
Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist.
Sparks SM, Aquino C, Banker P, Collins JL, Cowan D, Diaz C, Dock ST, Hertzog DL, Liang X, Swiger ED, Yuen J, Chen G, Jayawickreme C, Moncol D, Nystrom C, Rash V, Rimele T, Roller S, Ross S. Sparks SM, et al. Among authors: rimele t. Bioorg Med Chem Lett. 2017 Mar 1;27(5):1278-1283. doi: 10.1016/j.bmcl.2017.01.034. Epub 2017 Jan 17. Bioorg Med Chem Lett. 2017. PMID: 28148462
Discovery of 3-aryl-4-isoxazolecarboxamides as TGR5 receptor agonists.
Evans KA, Budzik BW, Ross SA, Wisnoski DD, Jin J, Rivero RA, Vimal M, Szewczyk GR, Jayawickreme C, Moncol DL, Rimele TJ, Armour SL, Weaver SP, Griffin RJ, Tadepalli SM, Jeune MR, Shearer TW, Chen ZB, Chen L, Anderson DL, Becherer JD, De Los Frailes M, Colilla FJ. Evans KA, et al. Among authors: rimele tj. J Med Chem. 2009 Dec 24;52(24):7962-5. doi: 10.1021/jm901434t. J Med Chem. 2009. PMID: 19902954
Functional screening in the melanophore bioassay.
Jayawickreme C, Sauls H, Watson C, Moncol D, Rimele T, Kenakin T. Jayawickreme C, et al. Among authors: rimele t. Curr Protoc Pharmacol. 2005 Jul;Chapter 12:Unit12.9. doi: 10.1002/0471141755.ph1209s29. Curr Protoc Pharmacol. 2005. PMID: 21953388
1,4-Benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonists.
Sherrill RG, Berman JM, Birkemo L, Croom DK, Dezube M, Ervin GN, Grizzle MK, James MK, Johnson MF, Queen KL, Rimele TJ, Vanmiddlesworth F, Sugg EE. Sherrill RG, et al. Among authors: rimele tj. Bioorg Med Chem Lett. 2001 May 7;11(9):1145-8. doi: 10.1016/s0960-894x(01)00164-0. Bioorg Med Chem Lett. 2001. PMID: 11354363
56 results