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C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases.
Zwarthoff SA, Widmer K, Kuipers A, Strasser J, Ruyken M, Aerts PC, de Haas CJC, Ugurlar D, den Boer MA, Vidarsson G, van Strijp JAG, Gros P, Parren PWHI, van Kessel KPM, Preiner J, Beurskens FJ, Schuurman J, Ricklin D, Rooijakkers SHM. Zwarthoff SA, et al. Among authors: ricklin d. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2102787118. doi: 10.1073/pnas.2102787118. Proc Natl Acad Sci U S A. 2021. PMID: 34155115 Free PMC article.
The extracellular adherence protein from Staphylococcus aureus inhibits the classical and lectin pathways of complement by blocking formation of the C3 proconvertase.
Woehl JL, Stapels DAC, Garcia BL, Ramyar KX, Keightley A, Ruyken M, Syriga M, Sfyroera G, Weber AB, Zolkiewski M, Ricklin D, Lambris JD, Rooijakkers SHM, Geisbrecht BV. Woehl JL, et al. Among authors: ricklin d. J Immunol. 2014 Dec 15;193(12):6161-6171. doi: 10.4049/jimmunol.1401600. Epub 2014 Nov 7. J Immunol. 2014. PMID: 25381436 Free PMC article.
129 results