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Improved Inhibition of Tumor Growth by Diabody-Drug Conjugates via Half-Life Extension.
Li Q, Barrett A, Vijayakrishnan B, Tiberghien A, Beard R, Rickert KW, Allen KL, Christie RJ, Marelli M, Harper J, Howard P, Wu H, Dall'Acqua WF, Tsui P, Gao C, Borrok MJ. Li Q, et al. Among authors: rickert kw. Bioconjug Chem. 2019 Apr 17;30(4):1232-1243. doi: 10.1021/acs.bioconjchem.9b00170. Epub 2019 Apr 3. Bioconjug Chem. 2019. PMID: 30912649
Targeted drug delivery via caveolae-associated protein PV1 improves lung fibrosis.
Marchetti GM, Burwell TJ, Peterson NC, Cann JA, Hanna RN, Li Q, Ongstad EL, Boyd JT, Kennedy MA, Zhao W, Rickert KW, Grimsby JS, Dall'Acqua WF, Wu H, Tsui P, Borrok MJ, Gupta R. Marchetti GM, et al. Among authors: rickert kw. Commun Biol. 2019 Mar 7;2:92. doi: 10.1038/s42003-019-0337-2. eCollection 2019. Commun Biol. 2019. PMID: 30854484 Free PMC article.
A Diene-Containing Noncanonical Amino Acid Enables Dual Functionality in Proteins: Rapid Diels-Alder Reaction with Maleimide or Proximity-Based Dimerization.
St Amant AH, Huang F, Lin J, Rickert K, Oganesyan V, Lemen D, Mao S, Harper J, Marelli M, Wu H, Gao C, Read de Alaniz J, Christie RJ. St Amant AH, et al. Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8489-8493. doi: 10.1002/anie.201903494. Epub 2019 May 14. Angew Chem Int Ed Engl. 2019. PMID: 31018033 Free PMC article.
The TGF-β inhibitory activity of antibody 37E1B5 depends on its H-CDR2 glycan.
Tsui P, Higazi DR, Wu Y, Dunmore R, Solier E, Kasali T, Bond NJ, Huntington C, Carruthers A, Hood J, Borrok MJ, Barnes A, Rickert K, Phipps S, Shirinian L, Zhu J, Bowen MA, Dall'Acqua W, Murray LA. Tsui P, et al. MAbs. 2017 Jan;9(1):104-113. doi: 10.1080/19420862.2016.1255390. Epub 2016 Nov 11. MAbs. 2017. PMID: 27834568 Free PMC article.
Ultrasmall targeted nanoparticles with engineered antibody fragments for imaging detection of HER2-overexpressing breast cancer.
Chen F, Ma K, Madajewski B, Zhuang L, Zhang L, Rickert K, Marelli M, Yoo B, Turker MZ, Overholtzer M, Quinn TP, Gonen M, Zanzonico P, Tuesca A, Bowen MA, Norton L, Subramony JA, Wiesner U, Bradbury MS. Chen F, et al. Nat Commun. 2018 Oct 8;9(1):4141. doi: 10.1038/s41467-018-06271-5. Nat Commun. 2018. PMID: 30297810 Free PMC article.
Target-Agnostic Identification of Functional Monoclonal Antibodies Against Klebsiella pneumoniae Multimeric MrkA Fimbrial Subunit.
Wang Q, Chang CS, Pennini M, Pelletier M, Rajan S, Zha J, Chen Y, Cvitkovic R, Sadowska A, Heidbrink Thompson J, Yu Lin H, Barnes A, Rickert K, Wilson S, Stover CK, Dall'Acqua WF, Chowdhury PS, Xiao X. Wang Q, et al. J Infect Dis. 2016 Jun 1;213(11):1800-8. doi: 10.1093/infdis/jiw021. Epub 2016 Jan 14. J Infect Dis. 2016. PMID: 26768253
Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
Katz JD, Jewell JP, Guerin DJ, Lim J, Dinsmore CJ, Deshmukh SV, Pan BS, Marshall CG, Lu W, Altman MD, Dahlberg WK, Davis L, Falcone D, Gabarda AE, Hang G, Hatch H, Holmes R, Kunii K, Lumb KJ, Lutterbach B, Mathvink R, Nazef N, Patel SB, Qu X, Reilly JF, Rickert KW, Rosenstein C, Soisson SM, Spencer KB, Szewczak AA, Walker D, Wang W, Young J, Zeng Q. Katz JD, et al. Among authors: rickert kw. J Med Chem. 2011 Jun 23;54(12):4092-108. doi: 10.1021/jm200112k. Epub 2011 May 24. J Med Chem. 2011. PMID: 21608528
Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design.
Cannon DA, Shan L, Du Q, Shirinian L, Rickert KW, Rosenthal KL, Korade M 3rd, van Vlerken-Ysla LE, Buchanan A, Vaughan TJ, Damschroder MM, Popovic B. Cannon DA, et al. Among authors: rickert kw. PLoS Comput Biol. 2019 May 1;15(5):e1006980. doi: 10.1371/journal.pcbi.1006980. eCollection 2019 May. PLoS Comput Biol. 2019. PMID: 31042706 Free PMC article.
50 results