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A randomized controlled trial showing safety and efficacy of a whole sporozoite vaccine against endemic malaria.
Sirima SB, Ouédraogo A, Tiono AB, Kaboré JM, Bougouma EC, Ouattara MS, Kargougou D, Diarra A, Henry N, Ouédraogo IN, Billingsley PF, Manoj A, Abebe Y, Kc N, Ruben A, Richie TL, James ER, Joshi S, Shrestha B, Strauss K, Lyke KE, Plowe CV, Potter GE, Cox C, Jones W, Sim BKL, Hoffman SL, Laurens MB. Sirima SB, et al. Among authors: richie tl. Sci Transl Med. 2022 Dec 7;14(674):eabj3776. doi: 10.1126/scitranslmed.abj3776. Epub 2022 Dec 7. Sci Transl Med. 2022. PMID: 36475905 Free PMC article. Clinical Trial.
Malaria field studies at NAMRU-2, Indonesia.
Baird JK, Jones TR, Bangs MJ, Richie TL, Hoffman SL. Baird JK, et al. Among authors: richie tl. Navy Med. 1993 Mar-Apr;84(2):14-20. Navy Med. 1993. PMID: 7808541 No abstract available.
Safety, tolerability, and lack of antibody responses after administration of a PfCSP DNA malaria vaccine via needle or needle-free jet injection, and comparison of intramuscular and combination intramuscular/intradermal routes.
Epstein JE, Gorak EJ, Charoenvit Y, Wang R, Freydberg N, Osinowo O, Richie TL, Stoltz EL, Trespalacios F, Nerges J, Ng J, Fallarme-Majam V, Abot E, Goh L, Parker S, Kumar S, Hedstrom RC, Norman J, Stout R, Hoffman SL. Epstein JE, et al. Among authors: richie tl. Hum Gene Ther. 2002 Sep 1;13(13):1551-60. doi: 10.1089/10430340260201644. Hum Gene Ther. 2002. PMID: 12228010
Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria.
Hoffman SL, Billingsley PF, James E, Richman A, Loyevsky M, Li T, Chakravarty S, Gunasekera A, Chattopadhyay R, Li M, Stafford R, Ahumada A, Epstein JE, Sedegah M, Reyes S, Richie TL, Lyke KE, Edelman R, Laurens MB, Plowe CV, Sim BK. Hoffman SL, et al. Among authors: richie tl. Hum Vaccin. 2010 Jan;6(1):97-106. doi: 10.4161/hv.6.1.10396. Epub 2010 Jan 21. Hum Vaccin. 2010. PMID: 19946222 Review.
Immune responses and protection of Aotus monkeys immunized with irradiated Plasmodium vivax sporozoites.
Jordán-Villegas A, Perdomo AB, Epstein JE, López J, Castellanos A, Manzano MR, Hernández MA, Soto L, Méndez F, Richie TL, Hoffman SL, Arévalo-Herrera M, Herrera S. Jordán-Villegas A, et al. Among authors: richie tl. Am J Trop Med Hyg. 2011 Feb;84(2 Suppl):43-50. doi: 10.4269/ajtmh.2011.09-0759. Am J Trop Med Hyg. 2011. PMID: 21292877 Free PMC article.
Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity.
Epstein JE, Tewari K, Lyke KE, Sim BK, Billingsley PF, Laurens MB, Gunasekera A, Chakravarty S, James ER, Sedegah M, Richman A, Velmurugan S, Reyes S, Li M, Tucker K, Ahumada A, Ruben AJ, Li T, Stafford R, Eappen AG, Tamminga C, Bennett JW, Ockenhouse CF, Murphy JR, Komisar J, Thomas N, Loyevsky M, Birkett A, Plowe CV, Loucq C, Edelman R, Richie TL, Seder RA, Hoffman SL. Epstein JE, et al. Among authors: richie tl. Science. 2011 Oct 28;334(6055):475-80. doi: 10.1126/science.1211548. Epub 2011 Sep 8. Science. 2011. PMID: 21903775 Clinical Trial.
A consultation on the optimization of controlled human malaria infection by mosquito bite for evaluation of candidate malaria vaccines.
Laurens MB, Duncan CJ, Epstein JE, Hill AV, Komisar JL, Lyke KE, Ockenhouse CF, Richie TL, Roestenberg M, Sauerwein RW, Spring MD, Talley AK, Moorthy VS; Consensus Group on Design of Clinical Trials of Controlled Human Malaria Infection. Laurens MB, et al. Among authors: richie tl. Vaccine. 2012 Aug 3;30(36):5302-4. doi: 10.1016/j.vaccine.2012.04.088. Epub 2012 May 31. Vaccine. 2012. PMID: 22659449
175 results