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Page 1
Induction of tier-2 neutralizing antibodies in mice with a DNA-encoded HIV envelope native like trimer.
Xu Z, Walker S, Wise MC, Chokkalingam N, Purwar M, Moore A, Tello-Ruiz E, Wu Y, Majumdar S, Konrath KM, Kulkarni A, Tursi NJ, Zaidi FI, Reuschel EL, Patel I, Obeirne A, Du J, Schultheis K, Gites L, Smith T, Mendoza J, Broderick KE, Humeau L, Pallesen J, Weiner DB, Kulp DW. Xu Z, et al. Among authors: reuschel el. Nat Commun. 2022 Feb 4;13(1):695. doi: 10.1038/s41467-022-28363-z. Nat Commun. 2022. PMID: 35121758 Free PMC article.
Immunogenicity of a DNA vaccine candidate for COVID-19.
Smith TRF, Patel A, Ramos S, Elwood D, Zhu X, Yan J, Gary EN, Walker SN, Schultheis K, Purwar M, Xu Z, Walters J, Bhojnagarwala P, Yang M, Chokkalingam N, Pezzoli P, Parzych E, Reuschel EL, Doan A, Tursi N, Vasquez M, Choi J, Tello-Ruiz E, Maricic I, Bah MA, Wu Y, Amante D, Park DH, Dia Y, Ali AR, Zaidi FI, Generotti A, Kim KY, Herring TA, Reeder S, Andrade VM, Buttigieg K, Zhao G, Wu JM, Li D, Bao L, Liu J, Deng W, Qin C, Brown AS, Khoshnejad M, Wang N, Chu J, Wrapp D, McLellan JS, Muthumani K, Wang B, Carroll MW, Kim JJ, Boyer J, Kulp DW, Humeau LMPF, Weiner DB, Broderick KE. Smith TRF, et al. Among authors: reuschel el. Nat Commun. 2020 May 20;11(1):2601. doi: 10.1038/s41467-020-16505-0. Nat Commun. 2020. PMID: 32433465 Free PMC article.
Novel prostate cancer immunotherapy with a DNA-encoded anti-prostate-specific membrane antigen monoclonal antibody.
Muthumani K, Marnin L, Kudchodkar SB, Perales-Puchalt A, Choi H, Agarwal S, Scott VL, Reuschel EL, Zaidi FI, Duperret EK, Wise MC, Kraynyak KA, Ugen KE, Sardesai NY, Joseph Kim J, Weiner DB. Muthumani K, et al. Among authors: reuschel el. Cancer Immunol Immunother. 2017 Dec;66(12):1577-1588. doi: 10.1007/s00262-017-2042-7. Epub 2017 Aug 17. Cancer Immunol Immunother. 2017. PMID: 28819703 Free PMC article.
INO-4800 DNA vaccine induces neutralizing antibodies and T cell activity against global SARS-CoV-2 variants.
Andrade VM, Christensen-Quick A, Agnes J, Tur J, Reed C, Kalia R, Marrero I, Elwood D, Schultheis K, Purwar M, Reuschel E, McMullan T, Pezzoli P, Kraynyak K, Sylvester A, Mammen MP, Tebas P, Joseph Kim J, Weiner DB, Smith TRF, Ramos SJ, Humeau LM, Boyer JD, Broderick KE. Andrade VM, et al. NPJ Vaccines. 2021 Oct 14;6(1):121. doi: 10.1038/s41541-021-00384-7. NPJ Vaccines. 2021. PMID: 34650089 Free PMC article.
SARS-CoV-2 Assays To Detect Functional Antibody Responses That Block ACE2 Recognition in Vaccinated Animals and Infected Patients.
Walker SN, Chokkalingam N, Reuschel EL, Purwar M, Xu Z, Gary EN, Kim KY, Helble M, Schultheis K, Walters J, Ramos S, Muthumani K, Smith TRF, Broderick KE, Tebas P, Patel A, Weiner DB, Kulp DW. Walker SN, et al. Among authors: reuschel el. J Clin Microbiol. 2020 Oct 21;58(11):e01533-20. doi: 10.1128/JCM.01533-20. Print 2020 Oct 21. J Clin Microbiol. 2020. PMID: 32855181 Free PMC article.
Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus.
Patel A, Reuschel EL, Xu Z, Zaidi FI, Kim KY, Scott DP, Mendoza J, Ramos S, Stoltz R, Feldmann F, Okumura A, Meade-White K, Haddock E, Thomas T, Rosenke R, Lovaglio J, Hanley PW, Saturday G, Muthumani K, Feldmann H, Humeau LM, Broderick KE, Weiner DB. Patel A, et al. Among authors: reuschel el. JCI Insight. 2021 May 24;6(10):e146082. doi: 10.1172/jci.insight.146082. JCI Insight. 2021. PMID: 33886507 Free PMC article.
Intradermal-delivered DNA vaccine induces durable immunity mediating a reduction in viral load in a rhesus macaque SARS-CoV-2 challenge model.
Patel A, Walters JN, Reuschel EL, Schultheis K, Parzych E, Gary EN, Maricic I, Purwar M, Eblimit Z, Walker SN, Guimet D, Bhojnagarwala P, Adeniji OS, Doan A, Xu Z, Elwood D, Reeder SM, Pessaint L, Kim KY, Cook A, Chokkalingam N, Finneyfrock B, Tello-Ruiz E, Dodson A, Choi J, Generotti A, Harrison J, Tursi NJ, Andrade VM, Dia Y, Zaidi FI, Andersen H, Abdel-Mohsen M, Lewis MG, Muthumani K, Kim JJ, Kulp DW, Humeau LM, Ramos SJ, Smith TRF, Weiner DB, Broderick KE. Patel A, et al. Among authors: reuschel el. Cell Rep Med. 2021 Oct 19;2(10):100420. doi: 10.1016/j.xcrm.2021.100420. Epub 2021 Sep 28. Cell Rep Med. 2021. PMID: 34604818 Free PMC article.
SARS-CoV-2 DNA Vaccine INO-4800 Induces Durable Immune Responses Capable of Being Boosted in a Phase 1 Open-Label Trial.
Kraynyak KA, Blackwood E, Agnes J, Tebas P, Giffear M, Amante D, Reuschel EL, Purwar M, Christensen-Quick A, Liu N, Andrade VM, Diehl MC, Wani S, Lupicka M, Sylvester A, Morrow MP, Pezzoli P, McMullan T, Kulkarni AJ, Zaidi FI, Frase D, Liaw K, Smith TRF, Ramos SJ, Ervin J, Adams M, Lee J, Dallas M, Shah Brown A, Shea JE, Kim JJ, Weiner DB, Broderick KE, Humeau LM, Boyer JD, Mammen MP. Kraynyak KA, et al. Among authors: reuschel el. J Infect Dis. 2022 Jun 1;225(11):1923-1932. doi: 10.1093/infdis/jiac016. J Infect Dis. 2022. PMID: 35079784 Free PMC article. Clinical Trial.
Nucleic acid delivery of immune-focused SARS-CoV-2 nanoparticles drives rapid and potent immunogenicity capable of single-dose protection.
Konrath KM, Liaw K, Wu Y, Zhu X, Walker SN, Xu Z, Schultheis K, Chokkalingam N, Chawla H, Du J, Tursi NJ, Moore A, Adolf-Bryfogle J, Purwar M, Reuschel EL, Frase D, Sullivan M, Fry B, Maricic I, Andrade VM, Iffland C, Crispin M, Broderick KE, Humeau LMPF, Patel A, Smith TRF, Pallesen J, Weiner DB, Kulp DW. Konrath KM, et al. Among authors: reuschel el. Cell Rep. 2022 Feb 1;38(5):110318. doi: 10.1016/j.celrep.2022.110318. Epub 2022 Jan 11. Cell Rep. 2022. PMID: 35090597 Free PMC article.
30 results