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Trop-2 induces ADAM10-mediated cleavage of E-cadherin and drives EMT-less metastasis in colon cancer.
Guerra E, Trerotola M, Relli V, Lattanzio R, Tripaldi R, Vacca G, Ceci M, Boujnah K, Garbo V, Moschella A, Zappacosta R, Simeone P, de Lange R, Weidle UH, Rotelli MT, Picciariello A, Depalo R, Querzoli P, Pedriali M, Bianchini E, Angelucci D, Pizzicannella G, Di Loreto C, Piantelli M, Antolini L, Sun XF, Altomare DF, Alberti S. Guerra E, et al. Among authors: relli v. Neoplasia. 2021 Sep;23(9):898-911. doi: 10.1016/j.neo.2021.07.002. Epub 2021 Jul 25. Neoplasia. 2021. PMID: 34320447 Free PMC article.
Trop-2 is a determinant of breast cancer survival.
Ambrogi F, Fornili M, Boracchi P, Trerotola M, Relli V, Simeone P, La Sorda R, Lattanzio R, Querzoli P, Pedriali M, Piantelli M, Biganzoli E, Alberti S. Ambrogi F, et al. Among authors: relli v. PLoS One. 2014 May 13;9(5):e96993. doi: 10.1371/journal.pone.0096993. eCollection 2014. PLoS One. 2014. PMID: 24824621 Free PMC article.
Epigenetic inheritance and the missing heritability.
Trerotola M, Relli V, Simeone P, Alberti S. Trerotola M, et al. Among authors: relli v. Hum Genomics. 2015 Jul 28;9(1):17. doi: 10.1186/s40246-015-0041-3. Hum Genomics. 2015. PMID: 26216216 Free PMC article. Review.
Trop-2 Induces Tumor Growth Through AKT and Determines Sensitivity to AKT Inhibitors.
Guerra E, Trerotola M, Tripaldi R, Aloisi AL, Simeone P, Sacchetti A, Relli V, D'Amore A, La Sorda R, Lattanzio R, Piantelli M, Alberti S. Guerra E, et al. Among authors: relli v. Clin Cancer Res. 2016 Aug 15;22(16):4197-205. doi: 10.1158/1078-0432.CCR-15-1701. Epub 2016 Mar 28. Clin Cancer Res. 2016. PMID: 27022065
Abandoning the Notion of Non-Small Cell Lung Cancer.
Relli V, Trerotola M, Guerra E, Alberti S. Relli V, et al. Trends Mol Med. 2019 Jul;25(7):585-594. doi: 10.1016/j.molmed.2019.04.012. Epub 2019 May 30. Trends Mol Med. 2019. PMID: 31155338 Review.
Trop-2, Na+/K+ ATPase, CD9, PKCα, cofilin assemble a membrane signaling super-complex that drives colorectal cancer growth and invasion.
Guerra E, Relli V, Ceci M, Tripaldi R, Simeone P, Aloisi AL, Pantalone L, La Sorda R, Lattanzio R, Sacchetti A, Havas K, Guarnieri S, Vergara D, Fournier I, Salzet M, Tinari N, Piantelli M, Trerotola M, Alberti S. Guerra E, et al. Among authors: relli v. Oncogene. 2022 Mar;41(12):1795-1808. doi: 10.1038/s41388-022-02220-1. Epub 2022 Feb 7. Oncogene. 2022. PMID: 35132180
3D-Informed Targeting of the Trop-2 Signal-Activation Site Drives Selective Cancer Vulnerability.
Guerra E, Trerotola M, Relli V, Lattanzio R, Tripaldi R, Ceci M, Boujnah K, Pantalone L, Sacchetti A, Havas KM, Simeone P, Travali N, Querzoli P, Pedriali M, Roversi P, Iezzi M, Tinari N, Antolini L, Alberti S. Guerra E, et al. Among authors: relli v. Mol Cancer Ther. 2023 Jun 1;22(6):790-804. doi: 10.1158/1535-7163.MCT-22-0352. Mol Cancer Ther. 2023. PMID: 36921314
15 results