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Obesity causes mitochondrial fragmentation and dysfunction in white adipocytes due to RalA activation.
Xia W, Veeragandham P, Cao Y, Xu Y, Rhyne TE, Qian J, Hung CW, Zhao P, Jones Y, Gao H, Liddle C, Yu RT, Downes M, Evans RM, Rydén M, Wabitsch M, Wang Z, Hakozaki H, Schöneberg J, Reilly SM, Huang J, Saltiel AR. Xia W, et al. Among authors: reilly sm. Nat Metab. 2024 Feb;6(2):273-289. doi: 10.1038/s42255-024-00978-0. Epub 2024 Jan 29. Nat Metab. 2024. PMID: 38286821 Free PMC article.
Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes.
Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M, Deluca JH, Dadpey B, Cho L, Pan A, Yu RT, Dai Y, Liddle C, Downes M, Evans RM, Lusis AJ, Laakso M, Chouchani ET, Rydén M, Saltiel AR. Keinan O, et al. Among authors: reilly sm. Nature. 2021 Nov;599(7884):296-301. doi: 10.1038/s41586-021-04019-8. Epub 2021 Oct 27. Nature. 2021. PMID: 34707293 Free PMC article.
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.
Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM. Fang S, et al. Among authors: reilly sm. Nat Med. 2015 Feb;21(2):159-65. doi: 10.1038/nm.3760. Epub 2015 Jan 5. Nat Med. 2015. PMID: 25559344 Free PMC article.
A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.
Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR. Reilly SM, et al. Nat Commun. 2015 Jan 12;6:6047. doi: 10.1038/ncomms7047. Nat Commun. 2015. PMID: 25581158 Free PMC article. Clinical Trial.
A futile approach to fighting obesity?
Reilly SM, Saltiel AR. Reilly SM, et al. Cell. 2015 Oct 22;163(3):539-40. doi: 10.1016/j.cell.2015.10.006. Epub 2015 Oct 22. Cell. 2015. PMID: 26496598 Free article.
Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.
Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR. Oral EA, et al. Among authors: reilly sm. Cell Metab. 2017 Jul 5;26(1):157-170.e7. doi: 10.1016/j.cmet.2017.06.006. Cell Metab. 2017. PMID: 28683283 Free PMC article. Clinical Trial.
Adapting to obesity with adipose tissue inflammation.
Reilly SM, Saltiel AR. Reilly SM, et al. Nat Rev Endocrinol. 2017 Nov;13(11):633-643. doi: 10.1038/nrendo.2017.90. Epub 2017 Aug 11. Nat Rev Endocrinol. 2017. PMID: 28799554 Review.
RalA controls glucose homeostasis by regulating glucose uptake in brown fat.
Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR. Skorobogatko Y, et al. Among authors: reilly sm. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7819-7824. doi: 10.1073/pnas.1801050115. Epub 2018 Jun 18. Proc Natl Acad Sci U S A. 2018. PMID: 29915037 Free PMC article.
119 results