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Adipocytes control hematopoiesis and inflammation through CD40 signaling.
Reiche ME, Poels K, Bosmans LA, Vos WG, Van Tiel CM, Gijbels MJJ, Aarts SABM, Den Toom M, Beckers L, Weber C, Atzler D, Rensen PCN, Kooijman S, Lutgens E. Reiche ME, et al. Haematologica. 2023 Jul 1;108(7):1873-1885. doi: 10.3324/haematol.2022.281482. Haematologica. 2023. PMID: 36475519 Free PMC article.
Macrophage CD40 plays a minor role in obesity-induced metabolic dysfunction.
Aarts SABM, Reiche ME, den Toom M, Beckers L, Gijbels MJJ, Gerdes N, de Winther MPJ, Lutgens E. Aarts SABM, et al. Among authors: reiche me. PLoS One. 2018 Aug 10;13(8):e0202150. doi: 10.1371/journal.pone.0202150. eCollection 2018. PLoS One. 2018. PMID: 30096208 Free PMC article.
Deficiency of the T cell regulator Casitas B-cell lymphoma-B aggravates atherosclerosis by inducing CD8+ T cell-mediated macrophage death.
Seijkens TTP, Poels K, Meiler S, van Tiel CM, Kusters PJH, Reiche M, Atzler D, Winkels H, Tjwa M, Poelman H, Slütter B, Kuiper J, Gijbels M, Kuivenhoven JA, Matic LP, Paulsson-Berne G, Hedin U, Hansson GK, Nicolaes GAF, Daemen MJAP, Weber C, Gerdes N, de Winther MPJ, Lutgens E. Seijkens TTP, et al. Eur Heart J. 2019 Jan 21;40(4):372-382. doi: 10.1093/eurheartj/ehy714. Eur Heart J. 2019. PMID: 30452556 Free PMC article.
Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis.
Aarts SA, Seijkens TT, Kusters PJ, van Tiel CM, Reiche ME, den Toom M, Beckers L, van Roomen CP, de Winther MP, Kooij G, Lutgens E. Aarts SA, et al. Among authors: reiche me. J Pathol. 2019 Apr;247(4):471-480. doi: 10.1002/path.5205. Epub 2019 Jan 30. J Pathol. 2019. PMID: 30471110 Free PMC article.
Peritoneal macrophages have an impaired immune response in obesity which can be reversed by subsequent weight loss.
Willemsen L, Neele AE, van der Velden S, Prange KHM, den Toom M, van Roomen CPAA, Reiche ME, Griffith GR, Gijbels MJJ, Lutgens E, de Winther MPJ. Willemsen L, et al. Among authors: reiche me. BMJ Open Diabetes Res Care. 2019 Nov 2;7(1):e000751. doi: 10.1136/bmjdrc-2019-000751. eCollection 2019. BMJ Open Diabetes Res Care. 2019. PMID: 31798899 Free PMC article.
Lose the helpers… get 'remote' regulators!
Reiche ME, Lutgens E. Reiche ME, et al. Cardiovasc Res. 2021 Feb 22;117(3):635-636. doi: 10.1093/cvr/cvaa197. Cardiovasc Res. 2021. PMID: 32637996 No abstract available.
Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular disease.
Lacy M, Bürger C, Shami A, Ahmadsei M, Winkels H, Nitz K, van Tiel CM, Seijkens TTP, Kusters PJH, Karshovka E, Prange KHM, Wu Y, Brouns SLN, Unterlugauer S, Kuijpers MJE, Reiche ME, Steffens S, Edsfeldt A, Megens RTA, Heemskerk JWM, Goncalves I, Weber C, Gerdes N, Atzler D, Lutgens E. Lacy M, et al. Among authors: reiche me. Nat Commun. 2021 Jun 18;12(1):3754. doi: 10.1038/s41467-021-23909-z. Nat Commun. 2021. PMID: 34145241 Free PMC article.
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