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Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function.
Yanai A, Huang K, Kang R, Singaraja RR, Arstikaitis P, Gan L, Orban PC, Mullard A, Cowan CM, Raymond LA, Drisdel RC, Green WN, Ravikumar B, Rubinsztein DC, El-Husseini A, Hayden MR. Yanai A, et al. Among authors: raymond la. Nat Neurosci. 2006 Jun;9(6):824-31. doi: 10.1038/nn1702. Epub 2006 May 14. Nat Neurosci. 2006. PMID: 16699508 Free PMC article.
Life without huntingtin: normal differentiation into functional neurons.
Metzler M, Chen N, Helgason CD, Graham RK, Nichol K, McCutcheon K, Nasir J, Humphries RK, Raymond LA, Hayden MR. Metzler M, et al. Among authors: raymond la. J Neurochem. 1999 Mar;72(3):1009-18. doi: 10.1046/j.1471-4159.1999.0721009.x. J Neurochem. 1999. PMID: 10037472 Free article.
Mutant huntingtin enhances excitotoxic cell death.
Zeron MM, Chen N, Moshaver A, Lee AT, Wellington CL, Hayden MR, Raymond LA. Zeron MM, et al. Among authors: raymond la. Mol Cell Neurosci. 2001 Jan;17(1):41-53. doi: 10.1006/mcne.2000.0909. Mol Cell Neurosci. 2001. PMID: 11161468
Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking.
Metzler M, Li B, Gan L, Georgiou J, Gutekunst CA, Wang Y, Torre E, Devon RS, Oh R, Legendre-Guillemin V, Rich M, Alvarez C, Gertsenstein M, McPherson PS, Nagy A, Wang YT, Roder JC, Raymond LA, Hayden MR. Metzler M, et al. Among authors: raymond la. EMBO J. 2003 Jul 1;22(13):3254-66. doi: 10.1093/emboj/cdg334. EMBO J. 2003. PMID: 12839988 Free PMC article.
179 results