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Identification of an in vivo orally active dual-binding protein-protein interaction inhibitor targeting TNFα through combined in silico/in vitro/in vivo screening.
Mouhsine H, Guillemain H, Moreau G, Fourati N, Zerrouki C, Baron B, Desallais L, Gizzi P, Ben Nasr N, Perrier J, Ratsimandresy R, Spadoni JL, Do H, England P, Montes M, Zagury JF. Mouhsine H, et al. Among authors: ratsimandresy r. Sci Rep. 2017 Jun 13;7(1):3424. doi: 10.1038/s41598-017-03427-z. Sci Rep. 2017. PMID: 28611375 Free PMC article.
Anti-cytokine therapeutics: history and update.
Ratsimandresy RA, Rappaport J, Zagury JF. Ratsimandresy RA, et al. Curr Pharm Des. 2009;15(17):1998-2025. doi: 10.2174/138161209788453130. Curr Pharm Des. 2009. PMID: 19519438 Review.
Active immunization against IL-23p19 improves experimental arthritis.
Ratsimandresy RA, Duvallet E, Assier E, Semerano L, Delavallée L, Bessis N, Zagury JF, Boissier MC. Ratsimandresy RA, et al. Vaccine. 2011 Nov 21;29(50):9329-36. doi: 10.1016/j.vaccine.2011.09.134. Epub 2011 Oct 18. Vaccine. 2011. PMID: 22008816
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).
Le Clerc S, Limou S, Coulonges C, Carpentier W, Dina C, Taing L, Delaneau O, Labib T, Sladek R; ANRS Genomic Group; Deveau C, Guillemain H, Ratsimandresy R, Montes M, Spadoni JL, Therwath A, Schächter F, Matsuda F, Gut I, Lelièvre JD, Lévy Y, Froguel P, Delfraissy JF, Hercberg S, Zagury JF. Le Clerc S, et al. Among authors: ratsimandresy r. J Infect Dis. 2009 Oct 15;200(8):1194-201. doi: 10.1086/605892. J Infect Dis. 2009. PMID: 19754311
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).
Limou S, Le Clerc S, Coulonges C, Carpentier W, Dina C, Delaneau O, Labib T, Taing L, Sladek R, Deveau C, Ratsimandresy R, Montes M, Spadoni JL, Lelièvre JD, Lévy Y, Therwath A, Schächter F, Matsuda F, Gut I, Froguel P, Delfraissy JF, Hercberg S, Zagury JF; ANRS Genomic Group. Limou S, et al. Among authors: ratsimandresy r. J Infect Dis. 2009 Feb 1;199(3):419-26. doi: 10.1086/596067. J Infect Dis. 2009. PMID: 19115949
POP1 inhibits MSU-induced inflammasome activation and ameliorates gout.
de Almeida L, Devi S, Indramohan M, Huang QQ, Ratsimandresy RA, Pope RM, Dorfleutner A, Stehlik C. de Almeida L, et al. Among authors: ratsimandresy ra. Front Immunol. 2022 Sep 26;13:912069. doi: 10.3389/fimmu.2022.912069. eCollection 2022. Front Immunol. 2022. PMID: 36225929 Free PMC article.
NLRP3 licenses NLRP11 for inflammasome activation in human macrophages.
Gangopadhyay A, Devi S, Tenguria S, Carriere J, Nguyen H, Jäger E, Khatri H, Chu LH, Ratsimandresy RA, Dorfleutner A, Stehlik C. Gangopadhyay A, et al. Among authors: ratsimandresy ra. Nat Immunol. 2022 Jun;23(6):892-903. doi: 10.1038/s41590-022-01220-3. Epub 2022 May 27. Nat Immunol. 2022. PMID: 35624206 Free PMC article.
Oncostatin M expression induced by bacterial triggers drives airway inflammatory and mucus secretion in severe asthma.
Headland SE, Dengler HS, Xu D, Teng G, Everett C, Ratsimandresy RA, Yan D, Kang J, Ganeshan K, Nazarova EV, Gierke S, Wedeles CJ, Guidi R, DePianto DJ, Morshead KB, Huynh A, Mills J, Flanagan S, Hambro S, Nunez V, Klementowicz JE, Shi Y, Wang J, Bevers J 3rd, Ramirez-Carrozzi V, Pappu R, Abbas A, Vander Heiden J, Choy DF, Yadav R, Modrusan Z, Panettieri RA Jr, Koziol-White C, Jester WF Jr, Jenkins BJ, Cao Y, Clarke C, Austin C, Lafkas D, Xu M, Wolters PJ, Arron JR, West NR, Wilson MS. Headland SE, et al. Among authors: ratsimandresy ra. Sci Transl Med. 2022 Jan 12;14(627):eabf8188. doi: 10.1126/scitranslmed.abf8188. Epub 2022 Jan 12. Sci Transl Med. 2022. PMID: 35020406
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