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HIF1α stabilization in hypoxia is not oxidant-initiated.
Kumar A, Vaish M, Karuppagounder SS, Gazaryan I, Cave JW, Starkov AA, Anderson ET, Zhang S, Pinto JT, Rountree AM, Wang W, Sweet IR, Ratan RR. Kumar A, et al. Among authors: ratan rr. Elife. 2021 Oct 1;10:e72873. doi: 10.7554/eLife.72873. Elife. 2021. PMID: 34596045 Free PMC article.
Harnessing hypoxic adaptation to prevent, treat, and repair stroke.
Ratan RR, Siddiq A, Smirnova N, Karpisheva K, Haskew-Layton R, McConoughey S, Langley B, Estevez A, Huerta PT, Volpe B, Roy S, Sen CK, Gazaryan I, Cho S, Fink M, LaManna J. Ratan RR, et al. J Mol Med (Berl). 2007 Dec;85(12):1331-8. doi: 10.1007/s00109-007-0283-1. Epub 2007 Nov 28. J Mol Med (Berl). 2007. PMID: 18043901 Free PMC article. Review.
Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury.
Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, Sen C, Beattie MS, Hart RP, Grumet M, Sun D, Freeman RS, Semenza GL, Gazaryan I. Ratan RR, et al. Ann N Y Acad Sci. 2008 Dec;1147:383-94. doi: 10.1196/annals.1427.033. Ann N Y Acad Sci. 2008. PMID: 19076458 Free PMC article.
Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.
McConoughey SJ, Basso M, Niatsetskaya ZV, Sleiman SF, Smirnova NA, Langley BC, Mahishi L, Cooper AJ, Antonyak MA, Cerione RA, Li B, Starkov A, Chaturvedi RK, Beal MF, Coppola G, Geschwind DH, Ryu H, Xia L, Iismaa SE, Pallos J, Pasternack R, Hils M, Fan J, Raymond LA, Marsh JL, Thompson LM, Ratan RR. McConoughey SJ, et al. Among authors: ratan rr. EMBO Mol Med. 2010 Sep;2(9):349-70. doi: 10.1002/emmm.201000084. EMBO Mol Med. 2010. PMID: 20665636 Free PMC article.
Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.
Haskew-Layton RE, Payappilly JB, Smirnova NA, Ma TC, Chan KK, Murphy TH, Guo H, Langley B, Sultana R, Butterfield DA, Santagata S, Alldred MJ, Gazaryan IG, Bell GW, Ginsberg SD, Ratan RR. Haskew-Layton RE, et al. Among authors: ratan rr. Proc Natl Acad Sci U S A. 2010 Oct 5;107(40):17385-90. doi: 10.1073/pnas.1003996107. Epub 2010 Sep 20. Proc Natl Acad Sci U S A. 2010. PMID: 20855618 Free PMC article.
171 results