Rash LD - Search Results

1

ASIC3: first the heartache, now a migraine!

Rash LD. Rash LD. Headache. 2013 Sep;53(8):1204-6. doi: 10.1111/head.12170. Headache. 2013. PMID: 24020955 No abstract available.

2

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.

Jensen JE, Durek T, Alewood PF, Adams DJ, King GF, Rash LD. Jensen JE, et al. Among authors: rash ld. Toxicon. 2009 Jul;54(1):56-61. doi: 10.1016/j.toxicon.2009.03.014. Epub 2009 Mar 21. Toxicon. 2009. PMID: 19306891

3

A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a.

Saez NJ, Mobli M, Bieri M, Chassagnon IR, Malde AK, Gamsjaeger R, Mark AE, Gooley PR, Rash LD, King GF. Saez NJ, et al. Among authors: rash ld. Mol Pharmacol. 2011 Nov;80(5):796-808. doi: 10.1124/mol.111.072207. Epub 2011 Aug 8. Mol Pharmacol. 2011. PMID: 21825095

4

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3.

Jensen JE, Mobli M, Brust A, Alewood PF, King GF, Rash LD. Jensen JE, et al. Among authors: rash ld. Mar Drugs. 2012 Jul;10(7):1511-1527. doi: 10.3390/md10071511. Epub 2012 Jul 16. Mar Drugs. 2012. PMID: 22851922 Free PMC article.

5

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3.

Anangi R, Rash LD, Mobli M, King GF. Anangi R, et al. Among authors: rash ld. Mar Drugs. 2012 Jul;10(7):1605-1618. doi: 10.3390/md10071605. Epub 2012 Jul 23. Mar Drugs. 2012. PMID: 22851929 Free PMC article.

6

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2.

Schroeder CI, Rash LD, Vila-Farrés X, Rosengren KJ, Mobli M, King GF, Alewood PF, Craik DJ, Durek T. Schroeder CI, et al. Among authors: rash ld. Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1017-20. doi: 10.1002/anie.201308898. Epub 2013 Dec 9. Angew Chem Int Ed Engl. 2014. PMID: 24323786

7

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores.

Jensen JE, Cristofori-Armstrong B, Anangi R, Rosengren KJ, Lau CH, Mobli M, Brust A, Alewood PF, King GF, Rash LD. Jensen JE, et al. Among authors: rash ld. J Med Chem. 2014 Nov 13;57(21):9195-203. doi: 10.1021/jm501400p. Epub 2014 Nov 4. J Med Chem. 2014. PMID: 25337890

8

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

Saez NJ, Deplazes E, Cristofori-Armstrong B, Chassagnon IR, Lin X, Mobli M, Mark AE, Rash LD, King GF. Saez NJ, et al. Among authors: rash ld. Br J Pharmacol. 2015 Oct;172(20):4985-95. doi: 10.1111/bph.13267. Epub 2015 Sep 22. Br J Pharmacol. 2015. PMID: 26248594 Free PMC article.

9

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.

Cristofori-Armstrong B, Soh MS, Talwar S, Brown DL, Griffin JD, Dekan Z, Stow JL, King GF, Lynch JW, Rash LD. Cristofori-Armstrong B, et al. Among authors: rash ld. Sci Rep. 2015 Oct 6;5:14763. doi: 10.1038/srep14763. Sci Rep. 2015. PMID: 26440210 Free PMC article.

10

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

Chassagnon IR, McCarthy CA, Chin YK, Pineda SS, Keramidas A, Mobli M, Pham V, De Silva TM, Lynch JW, Widdop RE, Rash LD, King GF. Chassagnon IR, et al. Among authors: rash ld. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):3750-3755. doi: 10.1073/pnas.1614728114. Epub 2017 Mar 20. Proc Natl Acad Sci U S A. 2017. PMID: 28320941 Free PMC article.

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