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p53-/- synergizes with enhanced NrasG12D signaling to transform megakaryocyte-erythroid progenitors in acute myeloid leukemia.
Zhang J, Kong G, Rajagopalan A, Lu L, Song J, Hussaini M, Zhang X, Ranheim EA, Liu Y, Wang J, Gao X, Chang YI, Johnson KD, Zhou Y, Yang D, Bhatnagar B, Lucas DM, Bresnick EH, Zhong X, Padron E, Zhang J. Zhang J, et al. Among authors: ranheim ea. Blood. 2017 Jan 19;129(3):358-370. doi: 10.1182/blood-2016-06-719237. Epub 2016 Nov 4. Blood. 2017. PMID: 27815262 Free PMC article.
Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation.
You X, Liu F, Binder M, Vedder A, Lasho T, Wen Z, Gao X, Flietner E, Rajagopalan A, Zhou Y, Finke C, Mangaonkar A, Liao R, Kong G, Ranheim EA, Droin N, Hunter AM, Nikolaev S, Balasis M, Abdel-Wahab O, Levine RL, Will B, Nadiminti KVG, Yang D, Geissler K, Solary E, Xu W, Padron E, Patnaik MM, Zhang J. You X, et al. Among authors: ranheim ea. Blood. 2022 Feb 17;139(7):1066-1079. doi: 10.1182/blood.2021012519. Blood. 2022. PMID: 34699595 Free PMC article.
Cis-regulatory mechanisms governing stem and progenitor cell transitions.
Johnson KD, Kong G, Gao X, Chang YI, Hewitt KJ, Sanalkumar R, Prathibha R, Ranheim EA, Dewey CN, Zhang J, Bresnick EH. Johnson KD, et al. Among authors: ranheim ea. Sci Adv. 2015 Sep 4;1(8):e1500503. doi: 10.1126/sciadv.1500503. eCollection 2015 Sep. Sci Adv. 2015. PMID: 26601269 Free PMC article.
GATA Factor-G-Protein-Coupled Receptor Circuit Suppresses Hematopoiesis.
Gao X, Wu T, Johnson KD, Lahvic JL, Ranheim EA, Zon LI, Bresnick EH. Gao X, et al. Among authors: ranheim ea. Stem Cell Reports. 2016 Mar 8;6(3):368-82. doi: 10.1016/j.stemcr.2016.01.008. Epub 2016 Feb 18. Stem Cell Reports. 2016. PMID: 26905203 Free PMC article.
Downregulating Notch counteracts KrasG12D-induced ERK activation and oxidative phosphorylation in myeloproliferative neoplasm.
Kong G, You X, Wen Z, Chang YI, Qian S, Ranheim EA, Letson C, Zhang X, Zhou Y, Liu Y, Rajagopalan A, Zhang J, Stieglitz E, Loh M, Hofmann I, Yang D, Zhong X, Padron E, Zhou L, Pear WS, Zhang J. Kong G, et al. Among authors: ranheim ea. Leukemia. 2019 Mar;33(3):671-685. doi: 10.1038/s41375-018-0248-0. Epub 2018 Sep 11. Leukemia. 2019. PMID: 30206308 Free PMC article.
Human leukemia mutations corrupt but do not abrogate GATA-2 function.
Katsumura KR, Mehta C, Hewitt KJ, Soukup AA, Fraga de Andrade I, Ranheim EA, Johnson KD, Bresnick EH. Katsumura KR, et al. Among authors: ranheim ea. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10109-E10118. doi: 10.1073/pnas.1813015115. Epub 2018 Oct 9. Proc Natl Acad Sci U S A. 2018. PMID: 30301799 Free PMC article.
Unique dependence on Sos1 in Kras G12D -induced leukemogenesis.
You X, Kong G, Ranheim EA, Yang D, Zhou Y, Zhang J. You X, et al. Among authors: ranheim ea. Blood. 2018 Dec 13;132(24):2575-2579. doi: 10.1182/blood-2018-09-874107. Epub 2018 Oct 30. Blood. 2018. PMID: 30377195 Free PMC article.
83 results