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Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents.
Hammill JT, Sviripa VM, Kril LM, Ortiz D, Fargo CM, Kim HS, Chen Y, Rector J, Rice AL, Domagalska MA, Begley KL, Liu C, Rangnekar VM, Dujardin JC, Watt DS, Landfear SM, Guy RK. Hammill JT, et al. Among authors: rangnekar vm. J Med Chem. 2021 Aug 26;64(16):12152-12162. doi: 10.1021/acs.jmedchem.1c00813. Epub 2021 Aug 6. J Med Chem. 2021. PMID: 34355566 Free PMC article.
Arylquins target vimentin to trigger Par-4 secretion for tumor cell apoptosis.
Burikhanov R, Sviripa VM, Hebbar N, Zhang W, Layton WJ, Hamza A, Zhan CG, Watt DS, Liu C, Rangnekar VM. Burikhanov R, et al. Among authors: rangnekar vm. Nat Chem Biol. 2014 Nov;10(11):924-926. doi: 10.1038/nchembio.1631. Epub 2014 Sep 14. Nat Chem Biol. 2014. PMID: 25218743 Free PMC article.
Par-4 secretion: stoichiometry of 3-arylquinoline binding to vimentin.
Sviripa VM, Burikhanov R, Obiero JM, Yuan Y, Nickell JR, Dwoskin LP, Zhan CG, Liu C, Tsodikov OV, Rangnekar VM, Watt DS. Sviripa VM, et al. Among authors: rangnekar vm. Org Biomol Chem. 2016 Jan 7;14(1):74-84. doi: 10.1039/c5ob01980j. Org Biomol Chem. 2016. PMID: 26548370 Free PMC article.
Crizotinib induces Par-4 secretion from normal cells and GRP78 expression on the cancer cell surface for selective tumor growth inhibition.
Burikhanov R, Ganguly S, Ellingson S, Sviripa VM, Araujo N, Li S, Venkatraman P, Rao M, Choughule A, Brainson CF, Zhan CG, Spielmann HP, Watt DS, Govindan R, Rangnekar VM. Burikhanov R, et al. Among authors: rangnekar vm. Am J Cancer Res. 2023 Mar 15;13(3):976-991. eCollection 2023. Am J Cancer Res. 2023. PMID: 37034206 Free PMC article.
130 results