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Piezo2 is the major transducer of mechanical forces for touch sensation in mice.
Ranade SS, Woo SH, Dubin AE, Moshourab RA, Wetzel C, Petrus M, Mathur J, Bégay V, Coste B, Mainquist J, Wilson AJ, Francisco AG, Reddy K, Qiu Z, Wood JN, Lewin GR, Patapoutian A. Ranade SS, et al. Nature. 2014 Dec 4;516(7529):121-5. doi: 10.1038/nature13980. Nature. 2014. PMID: 25471886 Free PMC article.
Piezo2 senses airway stretch and mediates lung inflation-induced apnoea.
Nonomura K, Woo SH, Chang RB, Gillich A, Qiu Z, Francisco AG, Ranade SS, Liberles SD, Patapoutian A. Nonomura K, et al. Among authors: ranade ss. Nature. 2017 Jan 12;541(7636):176-181. doi: 10.1038/nature20793. Epub 2016 Dec 21. Nature. 2017. PMID: 28002412 Free PMC article.
Piezo2 is required for Merkel-cell mechanotransduction.
Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, Stucky CL, Patapoutian A. Woo SH, et al. Nature. 2014 May 29;509(7502):622-6. doi: 10.1038/nature13251. Epub 2014 Apr 6. Nature. 2014. PMID: 24717433 Free PMC article.
Piezo1 links mechanical forces to red blood cell volume.
Cahalan SM, Lukacs V, Ranade SS, Chien S, Bandell M, Patapoutian A. Cahalan SM, et al. Among authors: ranade ss. Elife. 2015 May 22;4:e07370. doi: 10.7554/eLife.07370. Elife. 2015. PMID: 26001274 Free PMC article.
Mechanically Activated Ion Channels.
Ranade SS, Syeda R, Patapoutian A. Ranade SS, et al. Neuron. 2015 Sep 23;87(6):1162-1179. doi: 10.1016/j.neuron.2015.08.032. Neuron. 2015. PMID: 26402601 Free PMC article. Review.
Mechanically activated ion channel PIEZO1 is required for lymphatic valve formation.
Nonomura K, Lukacs V, Sweet DT, Goddard LM, Kanie A, Whitwam T, Ranade SS, Fujimori T, Kahn ML, Patapoutian A. Nonomura K, et al. Among authors: ranade ss. Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):12817-12822. doi: 10.1073/pnas.1817070115. Epub 2018 Nov 27. Proc Natl Acad Sci U S A. 2018. PMID: 30482854 Free PMC article.
82 results