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Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease.
Nat Microbiol. 2024 Mar;9(3):614-630. doi: 10.1038/s41564-024-01617-w. Epub 2024 Mar 1.
Nat Microbiol. 2024.
PMID: 38429422
The microbe-derived short-chain fatty acids butyrate and propionate are associated with protection from chronic GVHD.
Markey KA, Schluter J, Gomes ALC, Littmann ER, Pickard AJ, Taylor BP, Giardina PA, Weber D, Dai A, Docampo MD, Armijo GK, Slingerland AE, Slingerland JB, Nichols KB, Brereton DG, Clurman AG, Ramos RJ, Rao A, Bush A, Bohannon L, Covington M, Lew MV, Rizzieri DA, Chao N, Maloy M, Cho C, Politikos I, Giralt S, Taur Y, Pamer EG, Holler E, Perales MA, Ponce DM, Devlin SM, Xavier J, Sung AD, Peled JU, Cross JR, van den Brink MRM.
Markey KA, et al.
Blood. 2020 Jul 2;136(1):130-136. doi: 10.1182/blood.2019003369.
Blood. 2020.
PMID: 32430495
Free PMC article.
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Bacterial metabolism of bile acids promotes generation of peripheral regulatory T cells.
Campbell C, McKenney PT, Konstantinovsky D, Isaeva OI, Schizas M, Verter J, Mai C, Jin WB, Guo CJ, Violante S, Ramos RJ, Cross JR, Kadaveru K, Hambor J, Rudensky AY.
Campbell C, et al.
Nature. 2020 May;581(7809):475-479. doi: 10.1038/s41586-020-2193-0. Epub 2020 Apr 15.
Nature. 2020.
PMID: 32461639
Free PMC article.
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Infection leaves a genetic and functional mark on the gut population of a commensal bacterium.
Tawk C, Lim B, Bencivenga-Barry NA, Lees HJ, Ramos RJF, Cross J, Goodman AL.
Tawk C, et al. Among authors: ramos rjf.
Cell Host Microbe. 2023 May 10;31(5):811-826.e6. doi: 10.1016/j.chom.2023.04.005. Epub 2023 Apr 28.
Cell Host Microbe. 2023.
PMID: 37119822
Free PMC article.
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