Ramachandran R - Search Results

1

Structural-functional diversity of malaria parasite's PfHSP70-1 and PfHSP40 chaperone pair gives an edge over human orthologs in chaperone-assisted protein folding.

Anas M, Shukla A, Tripathi A, Kumari V, Prakash C, Nag P, Kumar LS, Sharma SK, Ramachandran R, Kumar N. Anas M, et al. Among authors: ramachandran r. Biochem J. 2020 Sep 30;477(18):3625-3643. doi: 10.1042/BCJ20200434. Biochem J. 2020. PMID: 32893851

2

Hsp70-1 from Plasmodium falciparum: protein stability, domain analysis and chaperone activity.

Misra G, Ramachandran R. Misra G, et al. Among authors: ramachandran r. Biophys Chem. 2009 Jun;142(1-3):55-64. doi: 10.1016/j.bpc.2009.03.006. Epub 2009 Mar 16. Biophys Chem. 2009. PMID: 19339102

3

Exploring the positional importance of aromatic residues and lysine in the interactions of peptides with the Plasmodium falciparum Hsp70-1.

Misra G, Ramachandran R. Misra G, et al. Among authors: ramachandran r. Biochim Biophys Acta. 2010 Nov;1804(11):2146-52. doi: 10.1016/j.bbapap.2010.08.007. Epub 2010 Aug 21. Biochim Biophys Acta. 2010. PMID: 20736089

4

Critical determinants for substrate recognition and catalysis in the M. tuberculosis class II AP-endonuclease/3'-5' exonuclease III.

Khanam T, Shukla A, Rai N, Ramachandran R. Khanam T, et al. Among authors: ramachandran r. Biochim Biophys Acta. 2015 May;1854(5):505-16. doi: 10.1016/j.bbapap.2015.02.019. Epub 2015 Mar 5. Biochim Biophys Acta. 2015. PMID: 25748880

5

Tricyclic dihydrobenzoxazepine and tetracyclic indole derivatives can specifically target bacterial DNA ligases and can distinguish them from human DNA ligase I.

Yadav N, Khanam T, Shukla A, Rai N, Hajela K, Ramachandran R. Yadav N, et al. Among authors: ramachandran r. Org Biomol Chem. 2015 May 21;13(19):5475-87. doi: 10.1039/c5ob00439j. Org Biomol Chem. 2015. PMID: 25875403

6

M. tuberculosis class II apurinic/ apyrimidinic-endonuclease/3'-5' exonuclease (XthA) engages with NAD+-dependent DNA ligase A (LigA) to counter futile cleavage and ligation cycles in base excision repair.

Khanam T, Afsar M, Shukla A, Alam F, Kumar S, Soyar H, Dolma K, Pasupuleti M, Srivastava KK, Ampapathi RS, Ramachandran R. Khanam T, et al. Among authors: ramachandran r. Nucleic Acids Res. 2020 May 7;48(8):4325-4343. doi: 10.1093/nar/gkaa188. Nucleic Acids Res. 2020. PMID: 32232338 Free PMC article.

7

Structure based identification of first-in-class fragment inhibitors that target the NMN pocket of M. tuberculosis NAD⁺-dependent DNA ligase A.

Shukla A, Afsar M, Kumar N, Kumar S, Ramachandran R. Shukla A, et al. Among authors: ramachandran r. J Struct Biol. 2021 Mar;213(1):107655. doi: 10.1016/j.jsb.2020.107655. Epub 2020 Nov 13. J Struct Biol. 2021. PMID: 33197566

8

Salt bridges at the subdomain interfaces of the adenylation domain and active-site residues of Mycobacterium tuberculosis NAD⁺-dependent DNA ligase A (MtbLigA) are important for the initial steps of nick-sealing activity.

Afsar M, Shukla A, Kumar N, Ramachandran R. Afsar M, et al. Among authors: ramachandran r. Acta Crystallogr D Struct Biol. 2021 Jun 1;77(Pt 6):776-789. doi: 10.1107/S2059798321003107. Epub 2021 May 14. Acta Crystallogr D Struct Biol. 2021. PMID: 34076591

9

Regulation of futile ligation during early steps of BER in M. tuberculosis is carried out by a β-clamp-XthA-LigA tri-component complex.

Shukla A, Afsar M, Khanam T, Kumar N, Ali F, Kumar S, Jahan F, Ramachandran R. Shukla A, et al. Among authors: ramachandran r. Int J Biol Macromol. 2023 Jan 15;225:442-453. doi: 10.1016/j.ijbiomac.2022.11.094. Epub 2022 Nov 14. Int J Biol Macromol. 2023. PMID: 36395952

10

Mycobacterium tuberculosis UsfX (Rv3287c) exhibits novel nucleotide binding and hydrolysis properties.

Malik SS, Luthra A, Srivastava SK, Ramachandran R. Malik SS, et al. Among authors: ramachandran r. Biochem Biophys Res Commun. 2008 Oct 24;375(3):465-70. doi: 10.1016/j.bbrc.2008.08.043. Epub 2008 Aug 21. Biochem Biophys Res Commun. 2008. PMID: 18722345

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