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The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia.
Lopez-Millan B, Costales P, Gutiérrez-Agüera F, Díaz de la Guardia R, Roca-Ho H, Vinyoles M, Rubio-Gayarre A, Safi R, Castaño J, Romecín PA, Ramírez-Orellana M, Anguita E, Jeremias I, Zamora L, Rodríguez-Manzaneque JC, Bueno C, Morís F, Menendez P. Lopez-Millan B, et al. Cancers (Basel). 2022 Mar 21;14(6):1593. doi: 10.3390/cancers14061593. Cancers (Basel). 2022. PMID: 35326743 Free PMC article.
Fratricide-resistant CD1a-specific CAR T cells for the treatment of cortical T-cell acute lymphoblastic leukemia.
Sánchez-Martínez D, Baroni ML, Gutierrez-Agüera F, Roca-Ho H, Blanch-Lombarte O, González-García S, Torrebadell M, Junca J, Ramírez-Orellana M, Velasco-Hernández T, Bueno C, Fuster JL, Prado JG, Calvo J, Uzan B, Cools J, Camos M, Pflumio F, Toribio ML, Menéndez P. Sánchez-Martínez D, et al. Blood. 2019 May 23;133(21):2291-2304. doi: 10.1182/blood-2018-10-882944. Epub 2019 Feb 22. Blood. 2019. PMID: 30796021 Free PMC article.
Impaired condensin complex and Aurora B kinase underlie mitotic and chromosomal defects in hyperdiploid B-cell ALL.
Molina O, Vinyoles M, Granada I, Roca-Ho H, Gutierrez-Agüera F, Valledor L, López-López CM, Rodríguez-González P, Trincado JL, Menéndez ST, Pal D, Ballerini P, den Boer ML, Plensa I, Mar Perez-Iribarne M, Rodríguez-Perales S, Calasanz MJ, Ramírez-Orellana M, Rodríguez R, Camós M, Calvo M, Bueno C, Menéndez P. Molina O, et al. Blood. 2020 Jul 16;136(3):313-327. doi: 10.1182/blood.2019002538. Blood. 2020. PMID: 32321174 Free PMC article. Clinical Trial.
Integrative methylome-transcriptome analysis unravels cancer cell vulnerabilities in infant MLL-rearranged B cell acute lymphoblastic leukemia.
Tejedor JR, Bueno C, Vinyoles M, Petazzi P, Agraz-Doblas A, Cobo I, Torres-Ruiz R, Bayón GF, Pérez RF, López-Tamargo S, Gutierrez-Agüera F, Santamarina-Ojeda P, Ramírez-Orellana M, Bardini M, Cazzaniga G, Ballerini P, Schneider P, Stam RW, Varela I, Fraga MF, Fernández AF, Menéndez P. Tejedor JR, et al. J Clin Invest. 2021 Jul 1;131(13):e138833. doi: 10.1172/JCI138833. J Clin Invest. 2021. PMID: 33983906 Free PMC article.
Engraftment characterization of risk-stratified AML in NSGS mice.
Díaz de la Guardia R, Velasco-Hernandez T, Gutiérrez-Agüera F, Roca-Ho H, Molina O, Nombela-Arrieta C, Bataller A, Fuster JL, Anguita E, Vives S, Zamora L, Nomdedeu J, Gómez-Casares MT, Ramírez-Orellana M, Lapillonne H, Ramos-Mejia V, Rodríguez-Manzaneque JC, Bueno C, Lopez-Millan B, Menéndez P. Díaz de la Guardia R, et al. Blood Adv. 2021 Dec 14;5(23):4842-4854. doi: 10.1182/bloodadvances.2020003958. Blood Adv. 2021. PMID: 34470043 Free PMC article.
Clonal heterogeneity and rates of specific chromosome gains are risk predictors in childhood high-hyperdiploid B-cell acute lymphoblastic leukemia.
Ramos-Muntada M, Trincado JL, Blanco J, Bueno C, Rodríguez-Cortez VC, Bataller A, López-Millán B, Schwab C, Ortega M, Velasco P, Blanco ML, Nomdedeu J, Ramírez-Orellana M, Minguela A, Fuster JL, Cuatrecasas E, Camós M, Ballerini P, Escherich G, Boer J, DenBoer M, Hernández-Rivas JM, Calasanz MJ, Cazzaniga G, Harrison CJ, Menéndez P, Molina O. Ramos-Muntada M, et al. Among authors: ramirez orellana m. Mol Oncol. 2022 Aug;16(16):2899-2919. doi: 10.1002/1878-0261.13276. Epub 2022 Jul 19. Mol Oncol. 2022. PMID: 35726693 Free PMC article.
TIM3, a human acute myeloid leukemia stem cell marker, does not enrich for leukemia-initiating stem cells in B-cell acute lymphoblastic leukemia.
Bueno C, Martínez A, Romecin PA, Zanetti SR, Tirtakusuma R, Genesca E, Camós M, Ramírez-Orellana M, Anguita E, Ballerini P, Locatelli F, Fuster JL, Menéndez P. Bueno C, et al. Among authors: ramirez orellana m. Haematologica. 2023 Aug 1;108(8):2229-2233. doi: 10.3324/haematol.2022.282394. Haematologica. 2023. PMID: 36655434 Free PMC article. No abstract available.
Inhibition of inflammatory signaling in Pax5 mutant cells mitigates B-cell leukemogenesis.
Isidro-Hernández M, Mayado A, Casado-García A, Martínez-Cano J, Palmi C, Fazio G, Orfao A, Ribera J, Ribera JM, Zamora L, Raboso-Gallego J, Blanco O, Alonso-López D, De Las Rivas J, Jiménez R, García Criado FJ, García Cenador MB, Ramírez-Orellana M, Cazzaniga G, Cobaleda C, Vicente-Dueñas C, Sánchez-García I. Isidro-Hernández M, et al. Sci Rep. 2020 Nov 5;10(1):19189. doi: 10.1038/s41598-020-76206-y. Sci Rep. 2020. PMID: 33154497 Free PMC article.
High-Dimensional Analysis of Single-Cell Flow Cytometry Data Predicts Relapse in Childhood Acute Lymphoblastic Leukaemia.
Chulián S, Martínez-Rubio Á, Pérez-García VM, Rosa M, Blázquez Goñi C, Rodríguez Gutiérrez JF, Hermosín-Ramos L, Molinos Quintana Á, Caballero-Velázquez T, Ramírez-Orellana M, Castillo Robleda A, Fernández-Martínez JL. Chulián S, et al. Cancers (Basel). 2020 Dec 23;13(1):17. doi: 10.3390/cancers13010017. Cancers (Basel). 2020. PMID: 33374500 Free PMC article.
41 results