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Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress.
Thomas A, Takahashi N, Rajapakse VN, Zhang X, Sun Y, Ceribelli M, Wilson KM, Zhang Y, Beck E, Sciuto L, Nichols S, Elenbaas B, Puc J, Dahmen H, Zimmermann A, Varonin J, Schultz CW, Kim S, Shimellis H, Desai P, Klumpp-Thomas C, Chen L, Travers J, McKnight C, Michael S, Itkin Z, Lee S, Yuno A, Lee MJ, Redon CE, Kindrick JD, Peer CJ, Wei JS, Aladjem MI, Figg WD, Steinberg SM, Trepel JB, Zenke FT, Pommier Y, Khan J, Thomas CJ. Thomas A, et al. Among authors: rajapakse vn. Cancer Cell. 2021 Apr 12;39(4):566-579.e7. doi: 10.1016/j.ccell.2021.02.014. Cancer Cell. 2021. PMID: 33848478 Free PMC article.
The histone variant H2A.X is a regulator of the epithelial-mesenchymal transition.
Weyemi U, Redon CE, Choudhuri R, Aziz T, Maeda D, Boufraqech M, Parekh PR, Sethi TK, Kasoji M, Abrams N, Merchant A, Rajapakse VN, Bonner WM. Weyemi U, et al. Among authors: rajapakse vn. Nat Commun. 2016 Feb 15;7:10711. doi: 10.1038/ncomms10711. Nat Commun. 2016. PMID: 26876487 Free PMC article.
The NCI-60 Methylome and Its Integration into CellMiner.
Reinhold WC, Varma S, Sunshine M, Rajapakse V, Luna A, Kohn KW, Stevenson H, Wang Y, Heyn H, Nogales V, Moran S, Goldstein DJ, Doroshow JH, Meltzer PS, Esteller M, Pommier Y. Reinhold WC, et al. Cancer Res. 2017 Feb 1;77(3):601-612. doi: 10.1158/0008-5472.CAN-16-0655. Epub 2016 Dec 6. Cancer Res. 2017. PMID: 27923837 Free PMC article.
Temozolomide in the Era of Precision Medicine.
Thomas A, Tanaka M, Trepel J, Reinhold WC, Rajapakse VN, Pommier Y. Thomas A, et al. Among authors: rajapakse vn. Cancer Res. 2017 Feb 15;77(4):823-826. doi: 10.1158/0008-5472.CAN-16-2983. Epub 2017 Feb 3. Cancer Res. 2017. PMID: 28159862 Free PMC article. Review.
SLFN11 Blocks Stressed Replication Forks Independently of ATR.
Murai J, Tang SW, Leo E, Baechler SA, Redon CE, Zhang H, Al Abo M, Rajapakse VN, Nakamura E, Jenkins LMM, Aladjem MI, Pommier Y. Murai J, et al. Among authors: rajapakse vn. Mol Cell. 2018 Feb 1;69(3):371-384.e6. doi: 10.1016/j.molcel.2018.01.012. Mol Cell. 2018. PMID: 29395061 Free PMC article.
35 results