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IL11 activates the placental inflammasome to drive preeclampsia.
Menkhorst E, Santos LL, Zhou W, Yang G, Winship AL, Rainczuk KE, Nguyen P, Zhang JG, Moore P, Williams M, Lê Cao KA, Mansell A, Dimitriadis E. Menkhorst E, et al. Among authors: rainczuk ke. Front Immunol. 2023 May 24;14:1175926. doi: 10.3389/fimmu.2023.1175926. eCollection 2023. Front Immunol. 2023. PMID: 37292200 Free PMC article.
Interleukin-11 alters placentation and causes preeclampsia features in mice.
Winship AL, Koga K, Menkhorst E, Van Sinderen M, Rainczuk K, Nagai M, Cuman C, Yap J, Zhang JG, Simmons D, Young MJ, Dimitriadis E. Winship AL, et al. Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15928-33. doi: 10.1073/pnas.1515076112. Epub 2015 Dec 11. Proc Natl Acad Sci U S A. 2015. PMID: 26655736 Free PMC article.
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