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IL18 Receptor Signaling Regulates Tumor-Reactive CD8+ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model.
Lutz V, Hellmund VM, Picard FSR, Raifer H, Ruckenbrod T, Klein M, Bopp T, Savai R, Duewell P, Keber CU, Weigert A, Chung HR, Buchholz M, Menke A, Gress TM, Huber M, Bauer C. Lutz V, et al. Among authors: raifer h. Cancer Immunol Res. 2023 Apr 3;11(4):421-434. doi: 10.1158/2326-6066.CIR-22-0398. Cancer Immunol Res. 2023. PMID: 36758176
Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation.
Visekruna A, Ritter J, Scholz T, Campos L, Guralnik A, Poncette L, Raifer H, Hagner S, Garn H, Staudt V, Bopp T, Reuter S, Taube C, Loser K, Huber M. Visekruna A, et al. Among authors: raifer h. Eur J Immunol. 2013 Mar;43(3):606-18. doi: 10.1002/eji.201242825. Epub 2013 Jan 31. Eur J Immunol. 2013. PMID: 23254356 Free article.
The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.
Raczkowski F, Ritter J, Heesch K, Schumacher V, Guralnik A, Höcker L, Raifer H, Klein M, Bopp T, Harb H, Kesper DA, Pfefferle PI, Grusdat M, Lang PA, Mittrücker HW, Huber M. Raczkowski F, et al. Among authors: raifer h. Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):15019-24. doi: 10.1073/pnas.1309378110. Epub 2013 Aug 26. Proc Natl Acad Sci U S A. 2013. PMID: 23980171 Free PMC article.
Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4.
Campos Carrascosa L, Klein M, Kitagawa Y, Lückel C, Marini F, König A, Guralnik A, Raifer H, Hagner-Benes S, Rädler D, Böck A, Kang C, Lohoff M, Garn H, Schaub B, Berberich-Siebelt F, Sakaguchi S, Bopp T, Huber M. Campos Carrascosa L, et al. Among authors: raifer h. Nat Commun. 2017 May 12;8:15366. doi: 10.1038/ncomms15366. Nat Commun. 2017. PMID: 28497800 Free PMC article.
IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection.
Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S, Strecker T, Viengkhou B, Jung SR, Obermann HL, Bauer S, Xu HC, Lang PA, Tom A, Lang KS, King NJC, Campbell IL, Hofer MJ. Huber M, et al. Among authors: raifer h. J Virol. 2017 Oct 27;91(22):e01219-17. doi: 10.1128/JVI.01219-17. Print 2017 Nov 15. J Virol. 2017. PMID: 28878077 Free PMC article.
Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells.
Lieber S, Reinartz S, Raifer H, Finkernagel F, Dreyer T, Bronger H, Jansen JM, Wagner U, Worzfeld T, Müller R, Huber M. Lieber S, et al. Among authors: raifer h. Oncoimmunology. 2018 Mar 15;7(5):e1424672. doi: 10.1080/2162402X.2018.1424672. eCollection 2018. Oncoimmunology. 2018. PMID: 29721385 Free PMC article.
Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells.
Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U. Visekruna A, et al. Among authors: raifer h. J Clin Invest. 2019 Apr 2;129(5):1972-1983. doi: 10.1172/JCI98929. eCollection 2019 Apr 2. J Clin Invest. 2019. PMID: 30939122 Free PMC article.
IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis.
Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. Lückel C, et al. Among authors: raifer h. Nat Commun. 2019 Dec 16;10(1):5722. doi: 10.1038/s41467-019-13731-z. Nat Commun. 2019. PMID: 31844089 Free PMC article.
Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer.
Salazar Y, Zheng X, Brunn D, Raifer H, Picard F, Zhang Y, Winter H, Guenther S, Weigert A, Weigmann B, Dumoutier L, Renauld JC, Waisman A, Schmall A, Tufman A, Fink L, Brüne B, Bopp T, Grimminger F, Seeger W, Pullamsetti SS, Huber M, Savai R. Salazar Y, et al. Among authors: raifer h. J Clin Invest. 2020 Jul 1;130(7):3560-3575. doi: 10.1172/JCI124037. J Clin Invest. 2020. PMID: 32229721 Free PMC article.
43 results