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Myeloid-derived itaconate suppresses cytotoxic CD8+ T cells and promotes tumour growth.
Zhao H, Teng D, Yang L, Xu X, Chen J, Jiang T, Feng AY, Zhang Y, Frederick DT, Gu L, Cai L, Asara JM, Pasca di Magliano M, Boland GM, Flaherty KT, Swanson KD, Liu D, Rabinowitz JD, Zheng B. Zhao H, et al. Among authors: rabinowitz jd. Nat Metab. 2022 Dec;4(12):1660-1673. doi: 10.1038/s42255-022-00676-9. Epub 2022 Nov 14. Nat Metab. 2022. PMID: 36376563 Free PMC article.
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Vander Heiden MG, et al. Among authors: rabinowitz jd. Science. 2010 Sep 17;329(5998):1492-9. doi: 10.1126/science.1188015. Science. 2010. PMID: 20847263 Free PMC article.
Autophagy maintains tumour growth through circulating arginine.
Poillet-Perez L, Xie X, Zhan L, Yang Y, Sharp DW, Hu ZS, Su X, Maganti A, Jiang C, Lu W, Zheng H, Bosenberg MW, Mehnert JM, Guo JY, Lattime E, Rabinowitz JD, White E. Poillet-Perez L, et al. Among authors: rabinowitz jd. Nature. 2018 Nov;563(7732):569-573. doi: 10.1038/s41586-018-0697-7. Epub 2018 Nov 14. Nature. 2018. PMID: 30429607 Free PMC article.
Serine Catabolism Feeds NADH when Respiration Is Impaired.
Yang L, Garcia Canaveras JC, Chen Z, Wang L, Liang L, Jang C, Mayr JA, Zhang Z, Ghergurovich JM, Zhan L, Joshi S, Hu Z, McReynolds MR, Su X, White E, Morscher RJ, Rabinowitz JD. Yang L, et al. Among authors: rabinowitz jd. Cell Metab. 2020 Apr 7;31(4):809-821.e6. doi: 10.1016/j.cmet.2020.02.017. Epub 2020 Mar 17. Cell Metab. 2020. PMID: 32187526 Free PMC article.
Quantitative Fluxomics of Circulating Metabolites.
Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD. Hui S, et al. Among authors: rabinowitz jd. Cell Metab. 2020 Oct 6;32(4):676-688.e4. doi: 10.1016/j.cmet.2020.07.013. Epub 2020 Aug 12. Cell Metab. 2020. PMID: 32791100 Free PMC article.
CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels.
Chini CCS, Peclat TR, Warner GM, Kashyap S, Espindola-Netto JM, de Oliveira GC, Gomez LS, Hogan KA, Tarragó MG, Puranik AS, Agorrody G, Thompson KL, Dang K, Clarke S, Childs BG, Kanamori KS, Witte MA, Vidal P, Kirkland AL, De Cecco M, Chellappa K, McReynolds MR, Jankowski C, Tchkonia T, Kirkland JL, Sedivy JM, van Deursen JM, Baker DJ, van Schooten W, Rabinowitz JD, Baur JA, Chini EN. Chini CCS, et al. Among authors: rabinowitz jd. Nat Metab. 2020 Nov;2(11):1284-1304. doi: 10.1038/s42255-020-00298-z. Epub 2020 Nov 16. Nat Metab. 2020. PMID: 33199925 Free PMC article.
Downregulation of the tyrosine degradation pathway extends Drosophila lifespan.
Parkhitko AA, Ramesh D, Wang L, Leshchiner D, Filine E, Binari R, Olsen AL, Asara JM, Cracan V, Rabinowitz JD, Brockmann A, Perrimon N. Parkhitko AA, et al. Among authors: rabinowitz jd. Elife. 2020 Dec 15;9:e58053. doi: 10.7554/eLife.58053. Elife. 2020. PMID: 33319750 Free PMC article.
The Source of Glycolytic Intermediates in Mammalian Tissues.
TeSlaa T, Bartman CR, Jankowski CSR, Zhang Z, Xu X, Xing X, Wang L, Lu W, Hui S, Rabinowitz JD. TeSlaa T, et al. Among authors: rabinowitz jd. Cell Metab. 2021 Feb 2;33(2):367-378.e5. doi: 10.1016/j.cmet.2020.12.020. Epub 2021 Jan 19. Cell Metab. 2021. PMID: 33472024 Free PMC article.
Restoring metabolism of myeloid cells reverses cognitive decline in ageing.
Minhas PS, Latif-Hernandez A, McReynolds MR, Durairaj AS, Wang Q, Rubin A, Joshi AU, He JQ, Gauba E, Liu L, Wang C, Linde M, Sugiura Y, Moon PK, Majeti R, Suematsu M, Mochly-Rosen D, Weissman IL, Longo FM, Rabinowitz JD, Andreasson KI. Minhas PS, et al. Among authors: rabinowitz jd. Nature. 2021 Feb;590(7844):122-128. doi: 10.1038/s41586-020-03160-0. Epub 2021 Jan 20. Nature. 2021. PMID: 33473210 Free PMC article.
296 results