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SHMT2 inhibition disrupts the TCF3 transcriptional survival program in Burkitt lymphoma.
Wilke AC, Doebele C, Zindel A, Lee KS, Rieke SA, Ceribelli M, Comoglio F, Phelan JD, Wang JQ, Pikman Y, Jahn D, Häupl B, Schneider C, Scheich S, Tosto FA, Bohnenberger H, Stauder P, Schnütgen F, Slabicki M, Coulibaly ZA, Wolf S, Bojarczuk K, Chapuy B, Brandts CH, Stroebel P, Lewis CA, Engelke M, Xu X, Kim H, Dang TH, Schmitz R, Hodson DJ, Stegmaier K, Urlaub H, Serve H, Schmitt CA, Kreuz F, Knittel G, Rabinowitz JD, Reinhardt HC, Vander Heiden MG, Thomas C, Staudt LM, Zenz T, Oellerich T. Wilke AC, et al. Among authors: rabinowitz jd. Blood. 2022 Jan 27;139(4):538-553. doi: 10.1182/blood.2021012081. Blood. 2022. PMID: 34624079 Free PMC article.
Evidence for an alternative glycolytic pathway in rapidly proliferating cells.
Vander Heiden MG, Locasale JW, Swanson KD, Sharfi H, Heffron GJ, Amador-Noguez D, Christofk HR, Wagner G, Rabinowitz JD, Asara JM, Cantley LC. Vander Heiden MG, et al. Among authors: rabinowitz jd. Science. 2010 Sep 17;329(5998):1492-9. doi: 10.1126/science.1188015. Science. 2010. PMID: 20847263 Free PMC article.
Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma.
Ducker GS, Ghergurovich JM, Mainolfi N, Suri V, Jeong SK, Hsin-Jung Li S, Friedman A, Manfredi MG, Gitai Z, Kim H, Rabinowitz JD. Ducker GS, et al. Among authors: rabinowitz jd. Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):11404-11409. doi: 10.1073/pnas.1706617114. Epub 2017 Oct 9. Proc Natl Acad Sci U S A. 2017. PMID: 29073064 Free PMC article.
Methionine synthase supports tumour tetrahydrofolate pools.
Ghergurovich JM, Xu X, Wang JZ, Yang L, Ryseck RP, Wang L, Rabinowitz JD. Ghergurovich JM, et al. Among authors: rabinowitz jd. Nat Metab. 2021 Nov;3(11):1512-1520. doi: 10.1038/s42255-021-00465-w. Epub 2021 Nov 18. Nat Metab. 2021. PMID: 34799699 Free PMC article.
Serine catabolism generates liver NADPH and supports hepatic lipogenesis.
Zhang Z, TeSlaa T, Xu X, Zeng X, Yang L, Xing G, Tesz GJ, Clasquin MF, Rabinowitz JD. Zhang Z, et al. Among authors: rabinowitz jd. Nat Metab. 2021 Dec;3(12):1608-1620. doi: 10.1038/s42255-021-00487-4. Epub 2021 Nov 29. Nat Metab. 2021. PMID: 34845393 Free PMC article.
Glycine homeostasis requires reverse SHMT flux.
McBride MJ, Hunter CJ, Zhang Z, TeSlaa T, Xu X, Ducker GS, Rabinowitz JD. McBride MJ, et al. Among authors: rabinowitz jd. Cell Metab. 2024 Jan 2;36(1):103-115.e4. doi: 10.1016/j.cmet.2023.12.001. Cell Metab. 2024. PMID: 38171330
295 results