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IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective immunity to control reactivation of chronic infection with Toxoplasma gondii.
Suzuki Y, Lutshumba J, Chen KC, Abdelaziz MH, Sa Q, Ochiai E. Suzuki Y, et al. Front Cell Infect Microbiol. 2023 Feb 15;13:1110508. doi: 10.3389/fcimb.2023.1110508. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 36875520 Free PMC article.
Deficiency in indoleamine-2, 3-dioxygenase induces upregulation of guanylate binding protein 1 and inducible nitric oxide synthase expression in the brain during cerebral infection with Toxoplasma gondii in genetically resistant BALB/c mice but not in genetically susceptible C57BL/6 mice.
Anand N, Lutshumba J, Whitlow M, Abdelaziz MH, Mani R, Suzuki Y. Anand N, et al. Microbes Infect. 2022 Apr-May;24(3):104908. doi: 10.1016/j.micinf.2021.104908. Epub 2021 Nov 13. Microbes Infect. 2022. PMID: 34781010 Free PMC article.