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IFN-γ production by brain-resident cells activates cerebral mRNA expression of a wide spectrum of molecules critical for both innate and T cell-mediated protective immunity to control reactivation of chronic infection with Toxoplasma gondii.
Front Cell Infect Microbiol. 2023 Feb 15;13:1110508. doi: 10.3389/fcimb.2023.1110508. eCollection 2023.
Front Cell Infect Microbiol. 2023.
PMID: 36875520
Free PMC article.
Human MHC class I molecule, HLA-A2.1, mediates activation of CD8+ T cell IFN-γ production and the T cell-dependent protection against reactivation of cerebral Toxoplasma infection.
Mani R, Abdelaziz MH, Michelon A, Suzuki Y.
Mani R, et al.
Front Immunol. 2022 Oct 13;13:1005059. doi: 10.3389/fimmu.2022.1005059. eCollection 2022.
Front Immunol. 2022.
PMID: 36311799
Free PMC article.
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Deficiency in indoleamine-2, 3-dioxygenase induces upregulation of guanylate binding protein 1 and inducible nitric oxide synthase expression in the brain during cerebral infection with Toxoplasma gondii in genetically resistant BALB/c mice but not in genetically susceptible C57BL/6 mice.
Anand N, Lutshumba J, Whitlow M, Abdelaziz MH, Mani R, Suzuki Y.
Anand N, et al.
Microbes Infect. 2022 Apr-May;24(3):104908. doi: 10.1016/j.micinf.2021.104908. Epub 2021 Nov 13.
Microbes Infect. 2022.
PMID: 34781010
Free PMC article.
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A pathway to cure chronic infection with Toxoplasma gondii through immunological intervention.
Suzuki Y.
Suzuki Y.
Parasitol Int. 2021 Apr;81:102259. doi: 10.1016/j.parint.2020.102259. Epub 2020 Dec 1.
Parasitol Int. 2021.
PMID: 33271362
Free PMC article.
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