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Simultaneous detection of single molecules and singulated ensembles of molecules enables immunoassays with broad dynamic range.
Anal Chem. 2011 Mar 15;83(6):2279-85. doi: 10.1021/ac103161b. Epub 2011 Feb 23.
Anal Chem. 2011.
PMID: 21344864
Free PMC article.
Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations.
Rissin DM, Kan CW, Campbell TG, Howes SC, Fournier DR, Song L, Piech T, Patel PP, Chang L, Rivnak AJ, Ferrell EP, Randall JD, Provuncher GK, Walt DR, Duffy DC.
Rissin DM, et al.
Nat Biotechnol. 2010 Jun;28(6):595-9. doi: 10.1038/nbt.1641. Epub 2010 May 23.
Nat Biotechnol. 2010.
PMID: 20495550
Free PMC article.
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