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GLP-1R signaling neighborhoods associate with the susceptibility to adverse drug reactions of incretin mimetics.
Wright SC, Motso A, Koutsilieri S, Beusch CM, Sabatier P, Berghella A, Blondel-Tepaz É, Mangenot K, Pittarokoilis I, Sismanoglou DC, Le Gouill C, Olsen JV, Zubarev RA, Lambert NA, Hauser AS, Bouvier M, Lauschke VM. Wright SC, et al. Nat Commun. 2023 Oct 9;14(1):6243. doi: 10.1038/s41467-023-41893-4. Nat Commun. 2023. PMID: 37813859 Free PMC article.
In-Cell Arrestin-Receptor Interaction Assays.
Zheng C, Javitch JA, Lambert NA, Donthamsetti P, Gurevich VV. Zheng C, et al. Curr Protoc. 2023 Oct;3(10):e890. doi: 10.1002/cpz1.890. Curr Protoc. 2023. PMID: 37787634
S-nitrosylation is required for β2AR desensitization and experimental asthma.
Fonseca FV, Raffay TM, Xiao K, McLaughlin PJ, Qian Z, Grimmett ZW, Adachi N, Wang B, Hausladen A, Cobb BA, Zhang R, Hess DT, Gaston B, Lambert NA, Reynolds JD, Premont RT, Stamler JS. Fonseca FV, et al. Mol Cell. 2022 Aug 18;82(16):3089-3102.e7. doi: 10.1016/j.molcel.2022.06.033. Epub 2022 Aug 4. Mol Cell. 2022. PMID: 35931084 Free PMC article.
11 results