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Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice.
J Biol Chem. 2020 Nov 27;295(48):16251-16266. doi: 10.1074/jbc.RA119.012330. Epub 2020 Sep 10.
J Biol Chem. 2020.
PMID: 32913125
Free PMC article.
Combined treatment with the phenolics (-)-epigallocatechin-3-gallate and ferulic acid improves cognition and reduces Alzheimer-like pathology in mice.
Mori T, Koyama N, Tan J, Segawa T, Maeda M, Town T.
Mori T, et al.
J Biol Chem. 2019 Feb 22;294(8):2714-2731. doi: 10.1074/jbc.RA118.004280. Epub 2018 Dec 18.
J Biol Chem. 2019.
PMID: 30563837
Free PMC article.
Item in Clipboard
Let's make microglia great again in neurodegenerative disorders.
Guillot-Sestier MV, Town T.
Guillot-Sestier MV, et al.
J Neural Transm (Vienna). 2018 May;125(5):751-770. doi: 10.1007/s00702-017-1792-x. Epub 2017 Oct 12.
J Neural Transm (Vienna). 2018.
PMID: 29027011
Free PMC article.
Review.
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Neuroinflammation in Alzheimer's disease.
Heneka MT, Carson MJ, El Khoury J, Landreth GE, Brosseron F, Feinstein DL, Jacobs AH, Wyss-Coray T, Vitorica J, Ransohoff RM, Herrup K, Frautschy SA, Finsen B, Brown GC, Verkhratsky A, Yamanaka K, Koistinaho J, Latz E, Halle A, Petzold GC, Town T, Morgan D, Shinohara ML, Perry VH, Holmes C, Bazan NG, Brooks DJ, Hunot S, Joseph B, Deigendesch N, Garaschuk O, Boddeke E, Dinarello CA, Breitner JC, Cole GM, Golenbock DT, Kummer MP.
Heneka MT, et al.
Lancet Neurol. 2015 Apr;14(4):388-405. doi: 10.1016/S1474-4422(15)70016-5.
Lancet Neurol. 2015.
PMID: 25792098
Free PMC article.
Review.
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