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Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail.
Aging (Albany NY). 2023 Mar 20;15(6):1808-1832. doi: 10.18632/aging.204600. Epub 2023 Mar 20.
Aging (Albany NY). 2023.
PMID: 36947713
Free PMC article.
Metformin and leucine increase satellite cells and collagen remodeling during disuse and recovery in aged muscle.
Petrocelli JJ, Mahmassani ZS, Fix DK, Montgomery JA, Reidy PT, McKenzie AI, de Hart NM, Ferrara PJ, Kelley JJ, Eshima H, Funai K, Drummond MJ.
Petrocelli JJ, et al.
FASEB J. 2021 Sep;35(9):e21862. doi: 10.1096/fj.202100883R.
FASEB J. 2021.
PMID: 34416035
Free PMC article.
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PGC-1α-Targeted Therapeutic Approaches to Enhance Muscle Recovery in Aging.
Petrocelli JJ, Drummond MJ.
Petrocelli JJ, et al.
Int J Environ Res Public Health. 2020 Nov 21;17(22):8650. doi: 10.3390/ijerph17228650.
Int J Environ Res Public Health. 2020.
PMID: 33233350
Free PMC article.
Review.
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