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NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling.
Tarasov M, Struckman HL, Olgar Y, Miller A, Demirtas M, Bogdanov V, Terentyeva R, Soltisz AM, Meng X, Min D, Sakuta G, Dunlap I, Duran AD, Foster MP, Davis JP, Terentyev D, Györke S, Veeraraghavan R, Radwański PB. Tarasov M, et al. J Clin Invest. 2023 Apr 3;133(7):e152071. doi: 10.1172/JCI152071. J Clin Invest. 2023. PMID: 36821382 Free PMC article.
MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia.
Uddin ME, Eisenmann ED, Li Y, Huang KM, Garrison DA, Talebi Z, Gibson AA, Jin Y, Nepal M, Bonilla IM, Fu Q, Sun X, Millar A, Tarasov M, Jay CE, Cui X, Einolf HJ, Pelis RM, Smith SA, Radwański PB, Sweet DH, König J, Fromm MF, Carnes CA, Hu S, Sparreboom A. Uddin ME, et al. Int J Mol Sci. 2022 Aug 3;23(15):8607. doi: 10.3390/ijms23158607. Int J Mol Sci. 2022. PMID: 35955741 Free PMC article.