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Methotrexate works remotely, from the gut.
Wu HJ. Wu HJ. Cell Host Microbe. 2021 Mar 10;29(3):325-326. doi: 10.1016/j.chom.2021.02.016. Cell Host Microbe. 2021. PMID: 33705703 Free article.
The gut-joint axis in rheumatoid arthritis.
Zaiss MM, Joyce Wu HJ, Mauro D, Schett G, Ciccia F. Zaiss MM, et al. Nat Rev Rheumatol. 2021 Apr;17(4):224-237. doi: 10.1038/s41584-021-00585-3. Epub 2021 Mar 5. Nat Rev Rheumatol. 2021. PMID: 33674813 Review.