R01 HL136414/HL/NHLBI NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2018	2
2019	6
2020	1
2021	2
2023	2
2024	2

1

Translation velocity determines the efficacy of engineered suppressor tRNAs on pathogenic nonsense mutations.

Bharti N, Santos L, Davyt M, Behrmann S, Eichholtz M, Jimenez-Sanchez A, Hong JS, Rab A, Sorscher EJ, Albers S, Ignatova Z. Bharti N, et al. Nat Commun. 2024 Apr 5;15(1):2957. doi: 10.1038/s41467-024-47258-9. Nat Commun. 2024. PMID: 38580646 Free PMC article.

2

N⁶-methyladenosine in 5' UTR does not promote translation initiation.

Guca E, Alarcon R, Palo MZ, Santos L, Alonso-Gil S, Davyt M, de Lima LHF, Boissier F, Das S, Zagrovic B, Puglisi JD, Hashem Y, Ignatova Z. Guca E, et al. Mol Cell. 2024 Feb 1;84(3):584-595.e6. doi: 10.1016/j.molcel.2023.12.028. Epub 2024 Jan 19. Mol Cell. 2024. PMID: 38244546 Free article.

3

Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases.

Davyt M, Bharti N, Ignatova Z. Davyt M, et al. J Biol Chem. 2023 Sep;299(9):105089. doi: 10.1016/j.jbc.2023.105089. Epub 2023 Jul 24. J Biol Chem. 2023. PMID: 37495112 Free PMC article. Review.

4

Engineered tRNAs suppress nonsense mutations in cells and in vivo.

Albers S, Allen EC, Bharti N, Davyt M, Joshi D, Perez-Garcia CG, Santos L, Mukthavaram R, Delgado-Toscano MA, Molina B, Kuakini K, Alayyoubi M, Park KJ, Acharya G, Gonzalez JA, Sagi A, Birket SE, Tearney GJ, Rowe SM, Manfredi C, Hong JS, Tachikawa K, Karmali P, Matsuda D, Sorscher EJ, Chivukula P, Ignatova Z. Albers S, et al. Nature. 2023 Jun;618(7966):842-848. doi: 10.1038/s41586-023-06133-1. Epub 2023 May 31. Nature. 2023. PMID: 37258671 Free PMC article.

5

The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue.

Sabusap CM, Joshi D, Simhaev L, Oliver KE, Senderowitz H, van Willigen M, Braakman I, Rab A, Sorscher EJ, Hong JS. Sabusap CM, et al. J Biol Chem. 2021 Jan-Jun;296:100598. doi: 10.1016/j.jbc.2021.100598. Epub 2021 Mar 26. J Biol Chem. 2021. PMID: 33781744 Free PMC article.

6

Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity.

Rauscher R, Bampi GB, Guevara-Ferrer M, Santos LA, Joshi D, Mark D, Strug LJ, Rommens JM, Ballmann M, Sorscher EJ, Oliver KE, Ignatova Z. Rauscher R, et al. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2010612118. doi: 10.1073/pnas.2010612118. Proc Natl Acad Sci U S A. 2021. PMID: 33468668 Free PMC article.

7

Global assessment of the integrated stress response in CF patient-derived airway and intestinal tissues.

Bampi GB, Rauscher R, Kirchner S, Oliver KE, Bijvelds MJC, Santos LA, Wagner J, Frizzell RA, de Jonge HR, Sorscher EJ, Ignatova Z. Bampi GB, et al. J Cyst Fibros. 2020 Nov;19(6):1021-1026. doi: 10.1016/j.jcf.2020.04.005. Epub 2020 May 23. J Cyst Fibros. 2020. PMID: 32451204 Free PMC article.

8

Cystic fibrosis precision therapeutics: Emerging considerations.

Joshi D, Ehrhardt A, Hong JS, Sorscher EJ. Joshi D, et al. Pediatr Pulmonol. 2019 Nov;54 Suppl 3(Suppl 3):S13-S17. doi: 10.1002/ppul.24547. Pediatr Pulmonol. 2019. PMID: 31715091 Free PMC article. Review.

9

Slowing ribosome velocity restores folding and function of mutant CFTR.

Oliver KE, Rauscher R, Mijnders M, Wang W, Wolpert MJ, Maya J, Sabusap CM, Kesterson RA, Kirk KL, Rab A, Braakman I, Hong JS, Hartman JL 4th, Ignatova Z, Sorscher EJ. Oliver KE, et al. J Clin Invest. 2019 Dec 2;129(12):5236-5253. doi: 10.1172/JCI124282. J Clin Invest. 2019. PMID: 31657788 Free PMC article.

10

A Humanized Yeast Phenomic Model of Deoxycytidine Kinase to Predict Genetic Buffering of Nucleoside Analog Cytotoxicity.

Santos SM, Icyuz M, Pound I, William D, Guo J, McKinney BA, Niederweis M, Rodgers J, Hartman JL IV. Santos SM, et al. Genes (Basel). 2019 Sep 30;10(10):770. doi: 10.3390/genes10100770. Genes (Basel). 2019. PMID: 31575041 Free PMC article.

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