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Loss of cardiomyocyte CYB5R3 impairs redox equilibrium and causes sudden cardiac death.
Carew NT, Schmidt HM, Yuan S, Galley JC, Hall R, Altmann HM, Hahn SA, Miller MP, Wood KC, Gabris B, Stapleton MC, Hartwick S, Fazzari M, Wu YL, Trebak M, Kaufman BA, McTiernan CF, Schopfer FJ, Navas P, Thibodeau PH, McNamara DM, Salama G, Straub AC. Carew NT, et al. J Clin Invest. 2022 Sep 15;132(18):e147120. doi: 10.1172/JCI147120. J Clin Invest. 2022. PMID: 36106636 Free PMC article.
Immunomodulatory actions of a kynurenine-derived endogenous electrophile.
Carreño M, Pires MF, Woodcock SR, Brzoska T, Ghosh S, Salvatore SR, Chang F, Khoo NKH, Dunn M, Connors N, Yuan S, Straub AC, Wendell SG, Kato GJ, Freeman BA, Ofori-Acquah SF, Sundd P, Schopfer FJ, Vitturi DA. Carreño M, et al. Sci Adv. 2022 Jul;8(26):eabm9138. doi: 10.1126/sciadv.abm9138. Epub 2022 Jun 29. Sci Adv. 2022. PMID: 35767602 Free PMC article.
Cooperation between CYB5R3 and NOX4 via coenzyme Q mitigates endothelial inflammation.
Yuan S, Hahn SA, Miller MP, Sanker S, Calderon MJ, Sullivan M, Dosunmu-Ogunbi AM, Fazzari M, Li Y, Reynolds M, Wood KC, St Croix CM, Stolz D, Cifuentes-Pagano E, Navas P, Shiva S, Schopfer FJ, Pagano PJ, Straub AC. Yuan S, et al. Redox Biol. 2021 Nov;47:102166. doi: 10.1016/j.redox.2021.102166. Epub 2021 Oct 14. Redox Biol. 2021. PMID: 34656824 Free PMC article.
Forestalling age-impaired angiogenesis and blood flow by targeting NOX: Interplay of NOX1, IL-6, and SASP in propagating cell senescence.
Li Y, Kračun D, Dustin CM, El Massry M, Yuan S, Goossen CJ, DeVallance ER, Sahoo S, St Hilaire C, Gurkar AU, Finkel T, Straub AC, Cifuentes-Pagano E, Pagano PJ. Li Y, et al. Proc Natl Acad Sci U S A. 2021 Oct 19;118(42):e2015666118. doi: 10.1073/pnas.2015666118. Proc Natl Acad Sci U S A. 2021. PMID: 34654740 Free PMC article.
44 results