R01 GM134539/GM/NIGMS NIH HHS/United States[Grants and Funding] - Search Results

Year	Number of Results
2019	2
2020	3
2021	4
2022	6
2023	4
2024	0

1

Coevolution combined with molecular dynamics simulations provides structural and mechanistic insights into the interactions between the integrator complex subunits.

Fongang B, Wadop YN, Zhu Y, Wagner EJ, Kudlicki A, Rowicka M. Fongang B, et al. Comput Struct Biotechnol J. 2023 Nov 19;21:5686-5697. doi: 10.1016/j.csbj.2023.11.022. eCollection 2023. Comput Struct Biotechnol J. 2023. PMID: 38074468 Free PMC article.

2

Bi-allelic variants in INTS11 are associated with a complex neurological disorder.

Tepe B, Macke EL, Niceta M, Weisz Hubshman M, Kanca O, Schultz-Rogers L, Zarate YA, Schaefer GB, Granadillo De Luque JL, Wegner DJ, Cogne B, Gilbert-Dussardier B, Le Guillou X, Wagner EJ, Pais LS, Neil JE, Mochida GH, Walsh CA, Magal N, Drasinover V, Shohat M, Schwab T, Schmitz C, Clark K, Fine A, Lanpher B, Gavrilova R, Blanc P, Burglen L, Afenjar A, Steel D, Kurian MA, Prabhakar P, Gößwein S, Di Donato N, Bertini ES; Undiagnosed Diseases Network; Wangler MF, Yamamoto S, Tartaglia M, Klee EW, Bellen HJ. Tepe B, et al. Am J Hum Genet. 2023 May 4;110(5):774-789. doi: 10.1016/j.ajhg.2023.03.012. Epub 2023 Apr 12. Am J Hum Genet. 2023. PMID: 37054711 Free PMC article.

3

PGC-1α senses the CBC of pre-mRNA to dictate the fate of promoter-proximally paused RNAPII.

Rambout X, Cho H, Blanc R, Lyu Q, Miano JM, Chakkalakal JV, Nelson GM, Yalamanchili HK, Adelman K, Maquat LE. Rambout X, et al. Mol Cell. 2023 Jan 19;83(2):186-202.e11. doi: 10.1016/j.molcel.2022.12.022. Mol Cell. 2023. PMID: 36669479 Free PMC article.

4

Integrator is a global promoter-proximal termination complex.

Wagner EJ, Tong L, Adelman K. Wagner EJ, et al. Mol Cell. 2023 Feb 2;83(3):416-427. doi: 10.1016/j.molcel.2022.11.012. Epub 2023 Jan 11. Mol Cell. 2023. PMID: 36634676 Free PMC article. Review.

5

Immune-profiling of SARS-CoV-2 viremic patients reveals dysregulated innate immune responses.

Sun X, Gao C, Zhao K, Yang Y, Rassadkina Y, Fajnzylber J, Regan J, Li JZ, Lichterfeld M, Yu XG. Sun X, et al. Front Immunol. 2022 Nov 9;13:984553. doi: 10.3389/fimmu.2022.984553. eCollection 2022. Front Immunol. 2022. PMID: 36439166 Free PMC article.

6

Integrator endonuclease drives promoter-proximal termination at all RNA polymerase II-transcribed loci.

Stein CB, Field AR, Mimoso CA, Zhao C, Huang KL, Wagner EJ, Adelman K. Stein CB, et al. Mol Cell. 2022 Nov 17;82(22):4232-4245.e11. doi: 10.1016/j.molcel.2022.10.004. Epub 2022 Oct 28. Mol Cell. 2022. PMID: 36309014 Free PMC article.

7

Inositol hexakisphosphate is required for Integrator function.

Lin MH, Jensen MK, Elrod ND, Huang KL, Welle KA, Wagner EJ, Tong L. Lin MH, et al. Nat Commun. 2022 Sep 30;13(1):5742. doi: 10.1038/s41467-022-33506-3. Nat Commun. 2022. PMID: 36180473 Free PMC article.

8

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.

Replogle JM, Saunders RA, Pogson AN, Hussmann JA, Lenail A, Guna A, Mascibroda L, Wagner EJ, Adelman K, Lithwick-Yanai G, Iremadze N, Oberstrass F, Lipson D, Bonnar JL, Jost M, Norman TM, Weissman JS. Replogle JM, et al. Cell. 2022 Jul 7;185(14):2559-2575.e28. doi: 10.1016/j.cell.2022.05.013. Epub 2022 Jun 9. Cell. 2022. PMID: 35688146 Free PMC article.

9

Rixosomal RNA degradation contributes to silencing of Polycomb target genes.

Zhou H, Stein CB, Shafiq TA, Shipkovenska G, Kalocsay M, Paulo JA, Zhang J, Luo Z, Gygi SP, Adelman K, Moazed D. Zhou H, et al. Nature. 2022 Apr;604(7904):167-174. doi: 10.1038/s41586-022-04598-0. Epub 2022 Mar 30. Nature. 2022. PMID: 35355014 Free PMC article.

10

Dynamic control of chromatin-associated m⁶A methylation regulates nascent RNA synthesis.

Xu W, He C, Kaye EG, Li J, Mu M, Nelson GM, Dong L, Wang J, Wu F, Shi YG, Adelman K, Lan F, Shi Y, Shen H. Xu W, et al. Mol Cell. 2022 Mar 17;82(6):1156-1168.e7. doi: 10.1016/j.molcel.2022.02.006. Epub 2022 Feb 25. Mol Cell. 2022. PMID: 35219383 Free PMC article.

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