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Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer.
DeAngelo SL, Dziechciarz S, Solanki S, Shin M, Zhao L, Balia A, El-Derany MO, Das NK, Castillo C, Bell HN, Paulo JA, Zhang Y, Rossiter NJ, McCulla EC, He J, Talukder I, Schafer ZT, Neamati N, Mancias JD, Koutmos M, Shah YM. DeAngelo SL, et al. bioRxiv [Preprint]. 2024 Apr 1:2024.03.29.587381. doi: 10.1101/2024.03.29.587381. bioRxiv. 2024. PMID: 38617233 Free PMC article. Preprint.
Lysosomal storage disease proteo/lipidomic profiling using nMOST links ferritinophagy with mitochondrial iron deficiencies in cells lacking NPC2.
Kraus F, He Y, Swarup S, Overmyer KA, Jiang Y, Brenner J, Capitanio C, Bieber A, Jen A, Nightingale NM, Anderson BJ, Lee C, Paulo JA, Smith IR, Plitzko JM, Schulman BA, Wilfling F, Coon JJ, Wade Harper J. Kraus F, et al. bioRxiv [Preprint]. 2024 Mar 27:2024.03.26.586828. doi: 10.1101/2024.03.26.586828. bioRxiv. 2024. PMID: 38585873 Free PMC article. Preprint.
Combinatorial selective ER-phagy remodels the ER during neurogenesis.
Hoyer MJ, Capitanio C, Smith IR, Paoli JC, Bieber A, Jiang Y, Paulo JA, Gonzalez-Lozano MA, Baumeister W, Wilfling F, Schulman BA, Harper JW. Hoyer MJ, et al. Nat Cell Biol. 2024 Mar;26(3):378-392. doi: 10.1038/s41556-024-01356-4. Epub 2024 Mar 1. Nat Cell Biol. 2024. PMID: 38429475 Free PMC article.
USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in mice.
Dang F, Bai L, Dong J, Hu X, Wang J, Paulo JA, Xiong Y, Liang X, Sun Y, Chen Y, Guo M, Wang X, Huang Z, Inuzuka H, Chen L, Chu C, Liu J, Zhang T, Rezaeian AH, Liu J, Kaniskan HÜ, Zhong B, Zhang J, Letko M, Jin J, Lan K, Wei W. Dang F, et al. Sci Transl Med. 2023 Dec 6;15(725):eadh7668. doi: 10.1126/scitranslmed.adh7668. Epub 2023 Dec 6. Sci Transl Med. 2023. PMID: 38055802
154 results