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2016 1
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Page 1
Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic.
Li D, Yu X, Kottur J, Gong W, Zhang Z, Storey AJ, Tsai YH, Uryu H, Shen Y, Byrum SD, Edmondson RD, Mackintosh SG, Cai L, Liu Z, Aggarwal AK, Tackett AJ, Liu J, Jin J, Wang GG. Li D, et al. Oncogene. 2022 Jun;41(24):3328-3340. doi: 10.1038/s41388-022-02340-8. Epub 2022 May 7. Oncogene. 2022. PMID: 35525905 Free PMC article.
A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models.
Yu X, Li D, Kottur J, Shen Y, Kim HS, Park KS, Tsai YH, Gong W, Wang J, Suzuki K, Parker J, Herring L, Kaniskan HÜ, Cai L, Jain R, Liu J, Aggarwal AK, Wang GG, Jin J. Yu X, et al. Sci Transl Med. 2021 Sep 29;13(613):eabj1578. doi: 10.1126/scitranslmed.abj1578. Epub 2021 Sep 29. Sci Transl Med. 2021. PMID: 34586829 Free PMC article.
Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma.
Herviou L, Ovejero S, Izard F, Karmous-Gadacha O, Gourzones C, Bellanger C, De Smedt E, Ma A, Vincent L, Cartron G, Jin J, De Bruyne E, Grimaud C, Julien E, Moreaux J. Herviou L, et al. Clin Epigenetics. 2021 Sep 16;13(1):174. doi: 10.1186/s13148-021-01160-z. Clin Epigenetics. 2021. PMID: 34530900 Free PMC article.
Harnessing the E3 Ligase KEAP1 for Targeted Protein Degradation.
Wei J, Meng F, Park KS, Yim H, Velez J, Kumar P, Wang L, Xie L, Chen H, Shen Y, Teichman E, Li D, Wang GG, Chen X, Kaniskan HÜ, Jin J. Wei J, et al. J Am Chem Soc. 2021 Sep 22;143(37):15073-15083. doi: 10.1021/jacs.1c04841. Epub 2021 Sep 14. J Am Chem Soc. 2021. PMID: 34520194 Free PMC article.
UV-induced reduction in Polycomb repression promotes epidermal pigmentation.
Li MY, Flora P, Pu H, Bar C, Silva J, Cohen I, Galbo PM Jr, Liu H, Yu X, Jin J, Koseki H, D'Orazio JA, Zheng D, Ezhkova E. Li MY, et al. Dev Cell. 2021 Sep 27;56(18):2547-2561.e8. doi: 10.1016/j.devcel.2021.08.006. Epub 2021 Sep 1. Dev Cell. 2021. PMID: 34473941 Free PMC article.
A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells.
Xu C, Meng F, Park KS, Storey AJ, Gong W, Tsai YH, Gibson E, Byrum SD, Li D, Edmondson RD, Mackintosh SG, Vedadi M, Cai L, Tackett AJ, Kaniskan HÜ, Jin J, Wang GG. Xu C, et al. Cell Chem Biol. 2022 Mar 17;29(3):386-397.e9. doi: 10.1016/j.chembiol.2021.08.004. Epub 2021 Aug 31. Cell Chem Biol. 2022. PMID: 34469831 Free PMC article.
57 results