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Alu complementary DNA is enriched in atrophic macular degeneration and triggers retinal pigmented epithelium toxicity via cytosolic innate immunity.
Fukuda S, Narendran S, Varshney A, Nagasaka Y, Wang SB, Ambati K, Apicella I, Pereira F, Fowler BJ, Yasuma T, Hirahara S, Yasuma R, Huang P, Yerramothu P, Makin RD, Wang M, Baker KL, Marion KM, Huang X, Baghdasaryan E, Ambati M, Ambati VL, Banerjee D, Bonilha VL, Tolstonog GV, Held U, Ogura Y, Terasaki H, Oshika T, Bhattarai D, Kim KB, Feldman SH, Aguirre JI, Hinton DR, Kerur N, Sadda SR, Schumann GG, Gelfand BD, Ambati J. Fukuda S, et al. Sci Adv. 2021 Oct;7(40):eabj3658. doi: 10.1126/sciadv.abj3658. Epub 2021 Sep 29. Sci Adv. 2021. PMID: 34586848 Free PMC article.
3D iPSC modeling of the retinal pigment epithelium-choriocapillaris complex identifies factors involved in the pathology of macular degeneration.
Manian KV, Galloway CA, Dalvi S, Emanuel AA, Mereness JA, Black W, Winschel L, Soto C, Li Y, Song Y, DeMaria W, Kumar A, Slukvin I, Schwartz MP, Murphy WL, Anand-Apte B, Chung M, Benoit DSW, Singh R. Manian KV, et al. Cell Stem Cell. 2021 May 6;28(5):846-862.e8. doi: 10.1016/j.stem.2021.02.006. Epub 2021 Mar 29. Cell Stem Cell. 2021. PMID: 33784497 Free PMC article.
Editorial.
Bonilha VL. Bonilha VL. Redox Biol. 2021 Jun;42:101941. doi: 10.1016/j.redox.2021.101941. Epub 2021 Mar 11. Redox Biol. 2021. PMID: 33771513 Free PMC article. No abstract available.
A human model of Batten disease shows role of CLN3 in phagocytosis at the photoreceptor-RPE interface.
Tang C, Han J, Dalvi S, Manian K, Winschel L, Volland S, Soto CA, Galloway CA, Spencer W, Roll M, Milliner C, Bonilha VL, Johnson TB, Latchney L, Weimer JM, Augustine EF, Mink JW, Gullapalli VK, Chung M, Williams DS, Singh R. Tang C, et al. Commun Biol. 2021 Feb 5;4(1):161. doi: 10.1038/s42003-021-01682-5. Commun Biol. 2021. PMID: 33547385 Free PMC article.
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