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Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells.
van der Werf I, Mondala PK, Steel SK, Balaian L, Ladel L, Mason CN, Diep RH, Pham J, Cloos J, Kaspers GJL, Chan WC, Mark A, La Clair JJ, Wentworth P, Fisch KM, Crews LA, Whisenant TC, Burkart MD, Donohoe ME, Jamieson CHM. van der Werf I, et al. Cell Rep Med. 2023 Mar 21;4(3):100962. doi: 10.1016/j.xcrm.2023.100962. Epub 2023 Mar 7. Cell Rep Med. 2023. PMID: 36889320 Free PMC article.
Reversal of malignant ADAR1 splice isoform switching with Rebecsinib.
Crews LA, Ma W, Ladel L, Pham J, Balaian L, Steel SK, Mondala PK, Diep RH, Wu CN, Mason CN, van der Werf I, Oliver I, Reynoso E, Pineda G, Whisenant TC, Wentworth P, La Clair JJ, Jiang Q, Burkart MD, Jamieson CHM. Crews LA, et al. Cell Stem Cell. 2023 Mar 2;30(3):250-263.e6. doi: 10.1016/j.stem.2023.01.008. Epub 2023 Feb 16. Cell Stem Cell. 2023. PMID: 36803553 Free PMC article.
Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution.
Jiang Q, Isquith J, Ladel L, Mark A, Holm F, Mason C, He Y, Mondala P, Oliver I, Pham J, Ma W, Reynoso E, Ali S, Morris IJ, Diep R, Nasamran C, Xu G, Sasik R, Rosenthal SB, Birmingham A, Coso S, Pineda G, Crews L, Donohoe ME, Venter JC, Whisenant T, Mesa RA, Alexandrov LB, Fisch KM, Jamieson C. Jiang Q, et al. Cell Rep. 2021 Jan 26;34(4):108670. doi: 10.1016/j.celrep.2020.108670. Cell Rep. 2021. PMID: 33503434 Free PMC article.