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Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization.
Chen J, Laverty DJ, Talele S, Bale A, Carlson BL, Porath KA, Bakken KK, Burgenske DM, Decker PA, Vaubel RA, Eckel-Passow JE, Bhargava R, Lou Z, Hamerlik P, Harley B, Elmquist WF, Nagel ZD, Gupta SK, Sarkaria JN. Chen J, et al. Sci Transl Med. 2024 Feb 14;16(734):eadj5962. doi: 10.1126/scitranslmed.adj5962. Epub 2024 Feb 14. Sci Transl Med. 2024. PMID: 38354228
Critical DNA damaging pathways in tumorigenesis.
Kloeber JA, Lou Z. Kloeber JA, et al. Semin Cancer Biol. 2022 Oct;85:164-184. doi: 10.1016/j.semcancer.2021.04.012. Epub 2021 Apr 24. Semin Cancer Biol. 2022. PMID: 33905873 Free PMC article. Review.