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P300 promotes tumor recurrence by regulating radiation-induced conversion of glioma stem cells to vascular-like cells.
Muthukrishnan SD, Kawaguchi R, Nair P, Prasad R, Qin Y, Johnson M, Wang Q, VanderVeer-Harris N, Pham A, Alvarado AG, Condro MC, Gao F, Gau R, Castro MG, Lowenstein PR, Deb A, Hinman JD, Pajonk F, Burns TC, Goldman SA, Geschwind DH, Kornblum HI. Muthukrishnan SD, et al. Nat Commun. 2022 Oct 19;13(1):6202. doi: 10.1038/s41467-022-33943-0. Nat Commun. 2022. PMID: 36261421 Free PMC article.
Effects of the DRD2/3 antagonist ONC201 and radiation in glioblastoma.
He L, Bhat K, Ioannidis A, Zhang L, Nguyen NT, Allen JE, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. He L, et al. Radiother Oncol. 2021 Aug;161:140-147. doi: 10.1016/j.radonc.2021.05.027. Epub 2021 Jun 5. Radiother Oncol. 2021. PMID: 34097975 Free PMC article.
Targeting Glioma Stem Cells.
Muftuoglu Y, Pajonk F. Muftuoglu Y, et al. Neurosurg Clin N Am. 2021 Apr;32(2):283-289. doi: 10.1016/j.nec.2021.01.002. Epub 2021 Feb 18. Neurosurg Clin N Am. 2021. PMID: 33781508 Free PMC article. Review.
The dopamine receptor antagonist trifluoperazine prevents phenotype conversion and improves survival in mouse models of glioblastoma.
Bhat K, Saki M, Vlashi E, Cheng F, Duhachek-Muggy S, Alli C, Yu G, Medina P, He L, Damoiseaux R, Pellegrini M, Zemke NR, Nghiemphu PL, Cloughesy TF, Liau LM, Kornblum HI, Pajonk F. Bhat K, et al. Proc Natl Acad Sci U S A. 2020 May 19;117(20):11085-11096. doi: 10.1073/pnas.1920154117. Epub 2020 May 1. Proc Natl Acad Sci U S A. 2020. PMID: 32358191 Free PMC article.
19 results