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RACK1 recruits STAT3 specifically to insulin and insulin-like growth factor 1 receptors for activation, which is important for regulating anchorage-independent growth.
Mol Cell Biol. 2006 Jan;26(2):413-24. doi: 10.1128/MCB.26.2.413-424.2006.
Mol Cell Biol. 2006.
PMID: 16382134
Free PMC article.
RACK1, an insulin-like growth factor I (IGF-I) receptor-interacting protein, modulates IGF-I-dependent integrin signaling and promotes cell spreading and contact with extracellular matrix.
Hermanto U, Zong CS, Li W, Wang LH.
Hermanto U, et al.
Mol Cell Biol. 2002 Apr;22(7):2345-65. doi: 10.1128/MCB.22.7.2345-2365.2002.
Mol Cell Biol. 2002.
PMID: 11884618
Free PMC article.
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Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation.
Zeng L, Sachdev P, Yan L, Chan JL, Trenkle T, McClelland M, Welsh J, Wang LH.
Zeng L, et al.
Mol Cell Biol. 2000 Dec;20(24):9212-24. doi: 10.1128/MCB.20.24.9212-9224.2000.
Mol Cell Biol. 2000.
PMID: 11094073
Free PMC article.
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Protein kinase C-delta is an important signaling molecule in insulin-like growth factor I receptor-mediated cell transformation.
Li W, Jiang YX, Zhang J, Soon L, Flechner L, Kapoor V, Pierce JH, Wang LH.
Li W, et al.
Mol Cell Biol. 1998 Oct;18(10):5888-98. doi: 10.1128/MCB.18.10.5888.
Mol Cell Biol. 1998.
PMID: 9742106
Free PMC article.
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Stat5 is a physiological substrate of the insulin receptor.
Chen J, Sadowski HB, Kohanski RA, Wang LH.
Chen J, et al.
Proc Natl Acad Sci U S A. 1997 Mar 18;94(6):2295-300. doi: 10.1073/pnas.94.6.2295.
Proc Natl Acad Sci U S A. 1997.
PMID: 9122188
Free PMC article.
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