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New target for inhibition of bacterial RNA polymerase: 'switch region'.
Srivastava A, Talaue M, Liu S, Degen D, Ebright RY, Sineva E, Chakraborty A, Druzhinin SY, Chatterjee S, Mukhopadhyay J, Ebright YW, Zozula A, Shen J, Sengupta S, Niedfeldt RR, Xin C, Kaneko T, Irschik H, Jansen R, Donadio S, Connell N, Ebright RH. Srivastava A, et al. Curr Opin Microbiol. 2011 Oct;14(5):532-43. doi: 10.1016/j.mib.2011.07.030. Epub 2011 Aug 19. Curr Opin Microbiol. 2011. PMID: 21862392 Free PMC article. Review.
Structures of RNA polymerase-antibiotic complexes.
Ho MX, Hudson BP, Das K, Arnold E, Ebright RH. Ho MX, et al. Curr Opin Struct Biol. 2009 Dec;19(6):715-23. doi: 10.1016/j.sbi.2009.10.010. Epub 2009 Nov 18. Curr Opin Struct Biol. 2009. PMID: 19926275 Free PMC article. Review.
The RNA polymerase "switch region" is a target for inhibitors.
Mukhopadhyay J, Das K, Ismail S, Koppstein D, Jang M, Hudson B, Sarafianos S, Tuske S, Patel J, Jansen R, Irschik H, Arnold E, Ebright RH. Mukhopadhyay J, et al. Cell. 2008 Oct 17;135(2):295-307. doi: 10.1016/j.cell.2008.09.033. Cell. 2008. PMID: 18957204 Free PMC article.