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Normal aging induces A1-like astrocyte reactivity.
Clarke LE, Liddelow SA, Chakraborty C, Münch AE, Heiman M, Barres BA. Clarke LE, et al. Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):E1896-E1905. doi: 10.1073/pnas.1800165115. Epub 2018 Feb 7. Proc Natl Acad Sci U S A. 2018. PMID: 29437957 Free PMC article.
Neurotoxic reactive astrocytes are induced by activated microglia.
Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Münch AE, Chung WS, Peterson TC, Wilton DK, Frouin A, Napier BA, Panicker N, Kumar M, Buckwalter MS, Rowitch DH, Dawson VL, Dawson TM, Stevens B, Barres BA. Liddelow SA, et al. Nature. 2017 Jan 26;541(7638):481-487. doi: 10.1038/nature21029. Epub 2017 Jan 18. Nature. 2017. PMID: 28099414 Free PMC article.
Glia keep synapse distribution under wraps.
Clarke LE, Barres BA. Clarke LE, et al. Cell. 2013 Jul 18;154(2):267-8. doi: 10.1016/j.cell.2013.06.045. Cell. 2013. PMID: 23870116 Free PMC article.