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Synthesis, enantioresolution, and activity profile of chiral 6-methyl-2,4-disubstituted pyridazin-3(2H)-ones as potent N-formyl peptide receptor agonists.
Cilibrizzi A, Schepetkin IA, Bartolucci G, Crocetti L, Dal Piaz V, Giovannoni MP, Graziano A, Kirpotina LN, Quinn MT, Vergelli C. Cilibrizzi A, et al. Among authors: quinn mt. Bioorg Med Chem. 2012 Jun 15;20(12):3781-92. doi: 10.1016/j.bmc.2012.04.043. Epub 2012 Apr 27. Bioorg Med Chem. 2012. PMID: 22607879 Free PMC article.
Further studies on 2-arylacetamide pyridazin-3(2H)-ones: design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists.
Giovannoni MP, Schepetkin IA, Cilibrizzi A, Crocetti L, Khlebnikov AI, Dahlgren C, Graziano A, Dal Piaz V, Kirpotina LN, Zerbinati S, Vergelli C, Quinn MT. Giovannoni MP, et al. Among authors: quinn mt. Eur J Med Chem. 2013 Jun;64:512-28. doi: 10.1016/j.ejmech.2013.03.066. Epub 2013 Apr 8. Eur J Med Chem. 2013. PMID: 23685570 Free PMC article.
Cinnoline derivatives as human neutrophil elastase inhibitors.
Giovannoni MP, Schepetkin IA, Crocetti L, Ciciani G, Cilibrizzi A, Guerrini G, Khlebnikov AI, Quinn MT, Vergelli C. Giovannoni MP, et al. Among authors: quinn mt. J Enzyme Inhib Med Chem. 2016 Aug;31(4):628-39. doi: 10.3109/14756366.2015.1057718. Epub 2015 Jul 21. J Enzyme Inhib Med Chem. 2016. PMID: 26194018 Free PMC article.
324 results