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PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
Berlin M, Cantley J, Bookbinder M, Bortolon E, Broccatelli F, Cadelina G, Chan EW, Chen H, Chen X, Cheng Y, Cheung TK, Davenport K, DiNicola D, Gordon D, Hamman BD, Harbin A, Haskell R, He M, Hole AJ, Januario T, Kerry PS, Koenig SG, Li L, Merchant M, Pérez-Dorado I, Pizzano J, Quinn C, Rose CM, Rousseau E, Soto L, Staben LR, Sun H, Tian Q, Wang J, Wang W, Ye CS, Ye X, Zhang P, Zhou Y, Yauch R, Dragovich PS. Berlin M, et al. Among authors: quinn c. J Med Chem. 2024 Jan 25;67(2):1262-1313. doi: 10.1021/acs.jmedchem.3c01781. Epub 2024 Jan 5. J Med Chem. 2024. PMID: 38180485
Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.
Cantley J, Ye X, Rousseau E, Januario T, Hamman BD, Rose CM, Cheung TK, Hinkle T, Soto L, Quinn C, Harbin A, Bortolon E, Chen X, Haskell R, Lin E, Yu SF, Del Rosario G, Chan E, Dunlap D, Koeppen H, Martin S, Merchant M, Grimmer M, Broccatelli F, Wang J, Pizzano J, Dragovich PS, Berlin M, Yauch RL. Cantley J, et al. Among authors: quinn c. Nat Commun. 2022 Nov 10;13(1):6814. doi: 10.1038/s41467-022-34562-5. Nat Commun. 2022. PMID: 36357397 Free PMC article.
Co-opting the E3 ligase KLHDC2 for targeted protein degradation by small molecules.
Hickey CM, Digianantonio KM, Zimmermann K, Harbin A, Quinn C, Patel A, Gareiss P, Chapman A, Tiberi B, Dobrodziej J, Corradi J, Cacace AM, Langley DR, Békés M. Hickey CM, et al. Among authors: quinn c. Nat Struct Mol Biol. 2024 Feb;31(2):311-322. doi: 10.1038/s41594-023-01146-w. Epub 2024 Jan 4. Nat Struct Mol Biol. 2024. PMID: 38177675
A transparent approach: Openness in forensic science reporting.
Ballantyne KN, Summersby S, Pearson JR, Nicol K, Pirie E, Quinn C, Kogios R. Ballantyne KN, et al. Among authors: quinn c. Forensic Sci Int Synerg. 2024 May 4;8:100474. doi: 10.1016/j.fsisyn.2024.100474. eCollection 2024. Forensic Sci Int Synerg. 2024. PMID: 38737993 Free PMC article. Review.
Author Correction: Stakeholder-driven transformative adaptation is needed for climate-smart nutrition security in sub-Saharan Africa.
Jennings S, Challinor A, Smith P, Macdiarmid JI, Pope E, Chapman S, Bradshaw C, Clark H, Vetter S, Fitton N, King R, Mwamakamba S, Madzivhandila T, Mashingaidze I, Chomba C, Nawiko M, Nyhodo B, Mazibuko N, Yeki P, Kuwali P, Kambwiri A, Kazi V, Kiama A, Songole A, Coskeran H, Quinn C, Sallu S, Dougill A, Whitfield S, Kunin B, Meebelo N, Jamali A, Kantande D, Makundi P, Mbungu W, Kayula F, Walker S, Zimba S, Galani Yamdeu JH, Kapulu N, Galdos MV, Eze S, Tripathi H, Sait S, Kepinski S, Likoya E, Greathead H, Smith HE, Mahop MT, Harwatt H, Muzammil M, Horgan G, Benton T. Jennings S, et al. Among authors: quinn c. Nat Food. 2024 Apr 29. doi: 10.1038/s43016-024-00988-x. Online ahead of print. Nat Food. 2024. PMID: 38684751 No abstract available.
1,584 results