Purkiss AG - Search Results

1

D-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition.

de Chiara C, Homšak M, Prosser GA, Douglas HL, Garza-Garcia A, Kelly G, Purkiss AG, Tate EW, de Carvalho LPS. de Chiara C, et al. Among authors: purkiss ag. Nat Chem Biol. 2020 Jun;16(6):686-694. doi: 10.1038/s41589-020-0498-9. Epub 2020 Mar 16. Nat Chem Biol. 2020. PMID: 32203411 Free PMC article.

2

IMP1 KH1 and KH2 domains create a structural platform with unique RNA recognition and re-modelling properties.

Dagil R, Ball NJ, Ogrodowicz RW, Hobor F, Purkiss AG, Kelly G, Martin SR, Taylor IA, Ramos A. Dagil R, et al. Among authors: purkiss ag. Nucleic Acids Res. 2019 May 7;47(8):4334-4348. doi: 10.1093/nar/gkz136. Nucleic Acids Res. 2019. PMID: 30864660 Free PMC article.

3

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Morris ER, Caswell SJ, Kunzelmann S, Arnold LH, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Among authors: purkiss ag. Nat Commun. 2020 Jun 23;11(1):3165. doi: 10.1038/s41467-020-16983-2. Nat Commun. 2020. PMID: 32576829 Free PMC article.

4

Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R_p- and S_p-dNTPαS Diastereomers.

Morris ER, Kunzelmann S, Caswell SJ, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Among authors: purkiss ag. Biochemistry. 2021 Jun 1;60(21):1682-1698. doi: 10.1021/acs.biochem.0c00944. Epub 2021 May 14. Biochemistry. 2021. PMID: 33988981 Free PMC article.

5

Structure of DNA-CMG-Pol epsilon elucidates the roles of the non-catalytic polymerase modules in the eukaryotic replisome.

Goswami P, Abid Ali F, Douglas ME, Locke J, Purkiss A, Janska A, Eickhoff P, Early A, Nans A, Cheung AMC, Diffley JFX, Costa A. Goswami P, et al. Nat Commun. 2018 Nov 29;9(1):5061. doi: 10.1038/s41467-018-07417-1. Nat Commun. 2018. PMID: 30498216 Free PMC article.

6

Structure of the cohesin loader Scc2.

Chao WC, Murayama Y, Muñoz S, Jones AW, Wade BO, Purkiss AG, Hu XW, Borg A, Snijders AP, Uhlmann F, Singleton MR. Chao WC, et al. Among authors: purkiss ag. Nat Commun. 2017 Jan 6;8:13952. doi: 10.1038/ncomms13952. Nat Commun. 2017. PMID: 28059076 Free PMC article.

7

Cryo-EM of human Arp2/3 complexes provides structural insights into actin nucleation modulation by ARPC5 isoforms.

von Loeffelholz O, Purkiss A, Cao L, Kjaer S, Kogata N, Romet-Lemonne G, Way M, Moores CA. von Loeffelholz O, et al. Biol Open. 2020 Jul 31;9(7):bio054304. doi: 10.1242/bio.054304. Biol Open. 2020. PMID: 32661131 Free PMC article.

8

Mechanism of substrate hydrolysis by the human nucleotide pool sanitiser DNPH1.

Rzechorzek NJ, Kunzelmann S, Purkiss AG, Silva Dos Santos M, MacRae JI, Taylor IA, Fugger K, West SC. Rzechorzek NJ, et al. Among authors: purkiss ag. Nat Commun. 2023 Oct 26;14(1):6809. doi: 10.1038/s41467-023-42544-4. Nat Commun. 2023. PMID: 37884503 Free PMC article.

9

Architecture and regulation of a GDNF-GFRα1 synaptic adhesion assembly.

Houghton FM, Adams SE, Ríos AS, Masino L, Purkiss AG, Briggs DC, Ledda F, McDonald NQ. Houghton FM, et al. Among authors: purkiss ag. Nat Commun. 2023 Nov 20;14(1):7551. doi: 10.1038/s41467-023-43148-8. Nat Commun. 2023. PMID: 37985758 Free PMC article.

10

Structural Basis of Eco1-Mediated Cohesin Acetylation.

Chao WC, Wade BO, Bouchoux C, Jones AW, Purkiss AG, Federico S, O'Reilly N, Snijders AP, Uhlmann F, Singleton MR. Chao WC, et al. Among authors: purkiss ag. Sci Rep. 2017 Mar 14;7:44313. doi: 10.1038/srep44313. Sci Rep. 2017. PMID: 28290497 Free PMC article.

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