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FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway.
Urra FA, Muñoz F, Córdova-Delgado M, Ramírez MP, Peña-Ahumada B, Rios M, Cruz P, Ahumada-Castro U, Bustos G, Silva-Pavez E, Pulgar R, Morales D, Varela D, Millas-Vargas JP, Retamal E, Ramírez-Rodríguez O, Pessoa-Mahana H, Pavani M, Ferreira J, Cárdenas C, Araya-Maturana R. Urra FA, et al. Among authors: pulgar r. Sci Rep. 2018 Sep 4;8(1):13190. doi: 10.1038/s41598-018-31367-9. Sci Rep. 2018. PMID: 30181620 Free PMC article.
An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells.
Donoso-Bustamante V, Borrego EA, Schiaffino-Bustamante Y, Gutiérrez DA, Millas-Vargas JP, Fuentes-Retamal S, Correa P, Carrillo I, Aguilera RJ, Miranda D, Chávez-Báez I, Pulgar R, Urra FA, Varela-Ramírez A, Araya-Maturana R. Donoso-Bustamante V, et al. Among authors: pulgar r. Bioorg Chem. 2020 Jul;100:103935. doi: 10.1016/j.bioorg.2020.103935. Epub 2020 May 18. Bioorg Chem. 2020. PMID: 32454391
A New Quinone-Based Inhibitor of Mitochondrial Complex I in D-Conformation, Producing Invasion Reduction and Sensitization to Venetoclax in Breast Cancer Cells.
Monroy-Cárdenas M, Andrades V, Almarza C, Vera MJ, Martínez J, Pulgar R, Amalraj J, Araya-Maturana R, Urra FA. Monroy-Cárdenas M, et al. Among authors: pulgar r. Antioxidants (Basel). 2023 Aug 10;12(8):1597. doi: 10.3390/antiox12081597. Antioxidants (Basel). 2023. PMID: 37627592 Free PMC article.
55 results