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Therapies for rare diseases: therapeutic modalities, progress and challenges ahead.
Tambuyzer E, Vandendriessche B, Austin CP, Brooks PJ, Larsson K, Miller Needleman KI, Valentine J, Davies K, Groft SC, Preti R, Oprea TI, Prunotto M. Tambuyzer E, et al. Among authors: prunotto m. Nat Rev Drug Discov. 2020 Feb;19(2):93-111. doi: 10.1038/s41573-019-0049-9. Epub 2019 Dec 13. Nat Rev Drug Discov. 2020. PMID: 31836861 Review.
New renal drug development to face chronic renal disease.
Moll S, Meier M, Formentini I, Pomposiello S, Prunotto M. Moll S, et al. Among authors: prunotto m. Expert Opin Drug Discov. 2014 Dec;9(12):1471-85. doi: 10.1517/17460441.2014.956075. Epub 2014 Sep 6. Expert Opin Drug Discov. 2014. PMID: 25195802 Review.
The kidney as a target organ in pharmaceutical research.
Prunotto M, Gabbiani G, Pomposiello S, Ghiggeri G, Moll S. Prunotto M, et al. Drug Discov Today. 2011 Mar;16(5-6):244-59. doi: 10.1016/j.drudis.2010.11.011. Epub 2010 Dec 1. Drug Discov Today. 2011. PMID: 21129499 Review.
Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease.
Wright MB, Varona Santos J, Kemmer C, Maugeais C, Carralot JP, Roever S, Molina J, Ducasa GM, Mitrofanova A, Sloan A, Ahmad A, Pedigo C, Ge M, Pressly J, Barisoni L, Mendez A, Sgrignani J, Cavalli A, Merscher S, Prunotto M, Fornoni A. Wright MB, et al. Among authors: prunotto m. Nat Commun. 2021 Aug 2;12(1):4662. doi: 10.1038/s41467-021-24890-3. Nat Commun. 2021. PMID: 34341345 Free PMC article.
Machine learning-powered antibiotics phenotypic drug discovery.
Zoffmann S, Vercruysse M, Benmansour F, Maunz A, Wolf L, Blum Marti R, Heckel T, Ding H, Truong HH, Prummer M, Schmucki R, Mason CS, Bradley K, Jacob AI, Lerner C, Araujo Del Rosario A, Burcin M, Amrein KE, Prunotto M. Zoffmann S, et al. Among authors: prunotto m. Sci Rep. 2019 Mar 21;9(1):5013. doi: 10.1038/s41598-019-39387-9. Sci Rep. 2019. PMID: 30899034 Free PMC article.
87 results