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Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones.
de Boer B, Prick J, Pruis MG, Keane P, Imperato MR, Jaques J, Brouwers-Vos AZ, Hogeling SM, Woolthuis CM, Nijk MT, Diepstra A, Wandinger S, Versele M, Attar RM, Cockerill PN, Huls G, Vellenga E, Mulder AB, Bonifer C, Schuringa JJ. de Boer B, et al. Among authors: pruis mg. Cancer Cell. 2018 Oct 8;34(4):674-689.e8. doi: 10.1016/j.ccell.2018.08.014. Epub 2018 Sep 20. Cancer Cell. 2018. PMID: 30245083 Free article.
The Glycolytic Gatekeeper PDK1 defines different metabolic states between genetically distinct subtypes of human acute myeloid leukemia.
Erdem A, Marin S, Pereira-Martins DA, Cortés R, Cunningham A, Pruis MG, de Boer B, van den Heuvel FAJ, Geugien M, Wierenga ATJ, Brouwers-Vos AZ, Rego EM, Huls G, Cascante M, Schuringa JJ. Erdem A, et al. Among authors: pruis mg. Nat Commun. 2022 Mar 1;13(1):1105. doi: 10.1038/s41467-022-28737-3. Nat Commun. 2022. PMID: 35232995 Free PMC article.
Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability.
Erdem A, Marin S, Pereira-Martins DA, Geugien M, Cunningham A, Pruis MG, Weinhäuser I, Gerding A, Bakker BM, Wierenga ATJ, Rego EM, Huls G, Cascante M, Schuringa JJ. Erdem A, et al. Among authors: pruis mg. Nat Commun. 2022 Apr 19;13(1):2013. doi: 10.1038/s41467-022-29639-0. Nat Commun. 2022. PMID: 35440568 Free PMC article.
Dietary methionine starvation impairs acute myeloid leukemia progression.
Cunningham A, Erdem A, Alshamleh I, Geugien M, Pruis M, Pereira-Martins DA, van den Heuvel FAJ, Wierenga ATJ, Ten Berge H, Dennebos R, van den Boom V, Hogeling SM, Weinhäuser I, Knops R, de Blaauw P, Heiner-Fokkema MR, Woolthuis C, Günther UL, Rego EM, Martens JHA, Jansen JH, Schwalbe H, Huls G, Schuringa JJ. Cunningham A, et al. Blood. 2022 Nov 10;140(19):2037-2052. doi: 10.1182/blood.2022017575. Blood. 2022. PMID: 35984907 Free article.
15 results